Oral Neutrophils: Underestimated Players in Oral Cancer.

Autor:	Domnich M; Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Riedesel J; Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Pylaeva E; Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Kürten CHL; Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Buer J; Institute of Medical Microbiology, University of Duisburg-Essen, Essen, Germany., Lang S; Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Jablonska J; Department of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2020 Oct 09; Vol. 11, pp. 565683. Date of Electronic Publication: 2020 Oct 09 (Print Publication: 2020).
DOI:	10.3389/fimmu.2020.565683
Abstrakt:	The composition of the oral milieu reflects oral health. Saliva provides an environment for multiple microorganisms, and contains soluble factors and immune cells. Neutrophils, which rapidly react on the changes in the microenvironment, are a major immune cell population in saliva and thus may serve as a biomarker for oral pathologies. This review focuses on salivary neutrophils in the oral cavity, their phenotype changes in physiological and pathological conditions, as well as on factors regulating oral neutrophil amount, activation and functionality, with special emphasis on oral cancer and its risk factors. (Copyright © 2020 Domnich, Riedesel, Pylaeva, Kürten, Buer, Lang and Jablonska.)
Databáze:	MEDLINE
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