Interferon lambda 4 can directly activate human CD19 + B cells and CD8 + T cells.

Autor:	Coto-Llerena M; Department of Biomedicine, Hepatology, University Hospital and University of Basel, Basel, Switzerland., Lepore M; Department of Biomedicine, Experimental Immunology, University Hospital and University of Basel, Basel, Switzerland., Spagnuolo J; Department of Biomedicine, Experimental Immunology, University Hospital and University of Basel, Basel, Switzerland., Di Blasi D; Department of Biomedicine, Hepatology, University Hospital and University of Basel, Basel, Switzerland.; Department of Biomedicine, Experimental Immunology, University Hospital and University of Basel, Basel, Switzerland., Calabrese D; Department of Biomedicine, Hepatology, University Hospital and University of Basel, Basel, Switzerland., Suslov A; Department of Biomedicine, Hepatology, University Hospital and University of Basel, Basel, Switzerland., Bantug G; Department of Biomedicine, Immunobiology, University Hospital and University of Basel, Basel, Switzerland., Duong FH; Department of Biomedicine, Hepatology, University Hospital and University of Basel, Basel, Switzerland., Terracciano LM; Molecular Pathology Division, Institute of Pathology, University Hospital Basel, Basel, Switzerland., De Libero G; Department of Biomedicine, Experimental Immunology, University Hospital and University of Basel, Basel, Switzerland gennaro.delibero@unibas.ch., Heim MH; Department of Biomedicine, Hepatology, University Hospital and University of Basel, Basel, Switzerland markus.heim@unibas.ch.; Division of Gastroenterology and Hepatology, Clarunis, University Center for Gastrointestinal and Liver Diseases, Basel, Switzerland.
Jazyk:	angličtina
Zdroj:	Life science alliance [Life Sci Alliance] 2020 Nov 06; Vol. 4 (1). Date of Electronic Publication: 2020 Nov 06 (Print Publication: 2021).
DOI:	10.26508/lsa.201900612
Abstrakt:	Compared with the ubiquitous expression of type I (IFNα and IFNβ) interferon receptors, type III (IFNλ) interferon receptors are mainly expressed in epithelial cells of mucosal barriers of the of the intestine and respiratory tract. Consequently, IFNλs are important for innate pathogen defense in the lung and intestine. IFNλs also determine the outcome of hepatitis C virus (HCV) infections, with IFNλ4 inhibiting spontaneous clearance of HCV. Because viral clearance is dependent on T cells, we explored if IFNλs can directly bind to and regulate human T cells. We found that human B cells and CD8 + T cells express the IFNλ receptor and respond to IFNλs, including IFNλ4. IFNλs were not inhibitors but weak stimulators of B- and T-cell responses. Furthermore, IFNλ4 showed neither synergistic nor antagonistic effects in co-stimulatory experiments with IFNλ1 or IFNα. Multidimensional flow cytometry of cells from liver biopsies of hepatitis patients from IFNλ4-producers showed accumulation of activated CD8 + T cells with a central memory-like phenotype. In contrast, CD8 + T cells with a senescent/exhausted phenotype were more abundant in IFNλ4-non-producers. It remains to be elucidated how IFNλ4 promotes CD8 T-cell responses and inhibits the host immunity to HCV infections. (© 2020 Coto-Llerena et al.)
Databáze:	MEDLINE
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