Artepillin C: A comprehensive review of its chemistry, bioavailability, and pharmacological properties.
Autor: | Shahinozzaman M; Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA. Electronic address: mshahin@umd.edu., Basak B; Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh., Emran R; Department of Biochemistry, Sher-e-Bangla Agricultural University, Dhaka 1207, Bangladesh; Department of Agricultural Extension (DAE), Khamarbari, Farmgate, Dhaka 1215, Bangladesh., Rozario P; Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh., Obanda DN; Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA. Electronic address: dobanda@umd.edu. |
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Jazyk: | angličtina |
Zdroj: | Fitoterapia [Fitoterapia] 2020 Nov; Vol. 147, pp. 104775. Date of Electronic Publication: 2020 Nov 03. |
DOI: | 10.1016/j.fitote.2020.104775 |
Abstrakt: | Artepillin C (ARC), a prenylated derivative of p-coumaric acid, is one of the major phenolic compounds found in Brazilian green propolis (BGP) and its botanical source Baccharis dracunculifolia. Numerous studies on ARC show that its beneficial health effects correlate with the health effects of both BGP and B. dracunculifolia. Its wide range of pharmacological benefits include antioxidant, antimicrobial, anti-inflammatory, anti-diabetic, neuroprotective, gastroprotective, immunomodulatory, and anti-cancer effects. Most studies have focused on anti-oxidation, inflammation, diabetic, and cancers using both in vitro and in vivo approaches. Mechanisms underlying anti-cancer properties of ARC are apoptosis induction, cell cycle arrest, and the inhibition of p21-activated kinase 1 (PAK1), a protein characterized in many human diseases/disorders including COVID-19 infection. Therefore, further pre-clinical and clinical studies with ARC are necessary to explore its potential as intervention for a wide variety of diseases including the recent pandemic coronaviral infection. This review summarizes the comprehensive data on the pharmacological effects of ARC and could be a guideline for its future study and therapeutic usage. (Published by Elsevier B.V.) |
Databáze: | MEDLINE |
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