Evaluation of Antimicrobial Efficacy of Calcium Hydroxide along with Proton Pump Inhibitor against Enterococcus Faecalis .

Autor:	Divakar N; Department of Conservative Dentistry and Endodontics, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India., Mohan SP; Department of Oral Pathology and Microbiology, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India., Pulyodan MK; Department of Conservative Dentistry and Endodontics, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India., Tom A; Department of Oral Pathology and Microbiology, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India., Karukayil D; Department of Oral Pathology and Microbiology, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India., Somasundaram M; Department of Oral Pathology and Microbiology, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India.
Jazyk:	angličtina
Zdroj:	Journal of pharmacy & bioallied sciences [J Pharm Bioallied Sci] 2020 Aug; Vol. 12 (Suppl 1), pp. S352-S354. Date of Electronic Publication: 2020 Aug 28.
DOI:	10.4103/jpbs.JPBS_104_20
Abstrakt:	Aim: The aim of this study was to evaluate in vitro the efficacy of pantoprazole, a proton pump inhibitor, alone, and in combination with calcium hydroxide against Enterococcus faecalis , a star survivor in endodontic pathology. Materials and Methods: Teeth were inoculated with E. faecalis strains MTCC 439 and were divided into groups. Group 1 used saline as the negative control, Group 2 used calcium hydroxide, Group 3 used pantoprazole alone, and Group 4 used calcium hydroxide along with pantoprazole. They were incubated and dentine harvesting was performed. Colonies were counted using a digital counting machine. Data were statistically analyzed. Results: Group 4 was found to be the most effective against the pathogen. Discussion: This study indicates that the association of calcium hydroxide with the proton pump inhibitor pantoprazole can be successfully used as an intracanal medicament against E. faecalis . Competing Interests: There are no conflicts of interest. (Copyright: © 2020 Journal of Pharmacy and Bioallied Sciences.)
Databáze:	MEDLINE
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