Subthalamic beta oscillations correlate with dopaminergic degeneration in experimental parkinsonism.

Autor: Haumesser JK; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité University Medicine Berlin, Berlin, Germany., Beck MH; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité University Medicine Berlin, Berlin, Germany., Pellegrini F; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité University Medicine Berlin, Berlin, Germany., Kühn J; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité University Medicine Berlin, Berlin, Germany., Neumann WJ; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité University Medicine Berlin, Berlin, Germany., Altschüler J; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité University Medicine Berlin, Berlin, Germany., Harnack D; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité University Medicine Berlin, Berlin, Germany; Department of Neurologic Rehabilitation, Kliniken Beelitz, Beelitz-Heilstätten, Germany., Kupsch A; Clinic of Neurology and Stereotactic Neurosurgery, Otto von Guericke University, Magdeburg, Germany., Nikulin VV; Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany., Kühn AA; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité University Medicine Berlin, Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), Germany., van Riesen C; Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité University Medicine Berlin, Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), Germany; Berlin Institute of Health (BIH), Berlin, Germany; Department of Neurology, University Medicine Göttingen, Göttingen, Germany. Electronic address: christoph.van-riesen@med.uni-goettingen.de.
Jazyk: angličtina
Zdroj: Experimental neurology [Exp Neurol] 2021 Jan; Vol. 335, pp. 113513. Date of Electronic Publication: 2020 Oct 24.
DOI: 10.1016/j.expneurol.2020.113513
Abstrakt: Excessive beta activity has been shown in local field potential recordings from the cortico-basal ganglia loop of Parkinson's disease patients and in its various animal models. Recent evidence suggests that enhanced beta oscillations may play a central role in the pathophysiology of the disorder and that beta activity may be directly linked to the motor impairment. However, the temporal evolution of exaggerated beta oscillations during the ongoing dopaminergic neurodegeneration and its relation to the motor impairment and histological changes are still unknown. We investigated motor behavioral, in-vivo electrophysiological (subthalamic nucleus, motor cortex) and histological changes (striatum, substantia nigra compacta) 2, 5, 10 and 20-30 days after a 6-hydroxydopamine injection into the medial forebrain bundle in Wistar rats. We found strong correlations between subthalamic beta power and motor impairment. No correlation was found for beta power in the primary motor cortex. Only subthalamic but not cortical beta power was strongly correlated with the histological markers of the dopaminergic neurodegeneration. Significantly increased subthalamic beta oscillations could be detected before this increase was found in primary motor cortex. At the latest observation time point, a significantly higher percentage of long beta bursts was found. Our study is the first to show a strong relation between subthalamic beta power and the dopaminergic neurodegeneration. Thus, we provide additional evidence for an important pathophysiological role of subthalamic beta oscillations and prolonged beta bursts in Parkinson's disease.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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