New nanocarried phenobarbital formulation: Maintains better control of pentylenetetrazole-Induced seizures.

Autor:	de Almeida LCN; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., de Andrade Marques B; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Silva RL; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Hamoy AO; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., de Mello VJ; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil., Borges RDS; NESBio, College of Pharmacy, Health Sciences Institute, Federal University of Pará, Belém, Pará, Brazil., Brito FSN; Nanobiotechnology Laboratory, Institute of Biological Sciences, Federal University of Pará, P.O. Box 479, 66075-110, Belém, Pará, Brazil., Longo E; Functional Materials Development Center (CDMF) - Federal University of São Carlos, Washington Luis Km 235, P.O. Box 676, 13565-905, São Carlos, São Paulo, Brazil., Anicete-Santos M; Nanobiotechnology Laboratory, Institute of Biological Sciences, Federal University of Pará, P.O. Box 479, 66075-110, Belém, Pará, Brazil., Hamoy M; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Jazyk:	angličtina
Zdroj:	Biotechnology reports (Amsterdam, Netherlands) [Biotechnol Rep (Amst)] 2020 Oct 09; Vol. 28, pp. e00539. Date of Electronic Publication: 2020 Oct 09 (Print Publication: 2020).
DOI:	10.1016/j.btre.2020.e00539
Abstrakt:	This study aims to evaluate the efficacy of slow release phenobarbital in the control of convulsions triggered by pentylenetetrazole (PTZ), verifying the time of permanence in the anticonvulsant effect through behavior and electroencephalographic records. A total of 162 male Wistar rats weighing between 100 and 120 g were divided into two groups, one for behavior analysis (n = 90) and biochemistry, and another for the acquisition of electrocorticographic record (n = 72). Hepatic enzymes were measured by obtaining a blood sample from the animals studied by means of a biochemical analysis. The procedures for electrode implant and electrocorticographic recordings were performed. The intercalation of phenobarbital in layered double hydroxide (LDH) nanocarrier allowed us to evaluate a new slow release pharmaceutical formulation based on methodologies that have proven longer residence time and lower side effects. This study demonstrates that phenobarbital can be a new perspective pharmaceutical formulation. Competing Interests: The authors report no declarations of interest. (© 2020 The Authors.)
Databáze:	MEDLINE
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