Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers.
| Autor: | Glubb DM; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Thompson DJ; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Aben KKH; Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.; Netherlands Comprehensive Cancer Organisation, Utrecht, the Netherlands., Alsulimani A; Division of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York., Amant F; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium., Annibali D; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium., Attia J; Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.; Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia., Barricarte A; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Navarra Public Health Institute, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain., Beckmann MW; Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany., Berchuck A; Department of Gynecologic Oncology, Duke University Hospital, Durham, North Carolina., Bermisheva M; Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia., Bernardini MQ; Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada., Bischof K; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway., Bjorge L; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway., Bodelon C; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland., Brand AH; Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.; University of Sydney, Sydney, New South Wales, Australia., Brenton JD; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Brinton LA; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland., Bruinsma F; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia., Buchanan DD; Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia.; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia., Burghaus S; Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany., Butzow R; Department of Pathology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Cai H; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Carney ME; John A. Burns School of Medicine, Department of Obstetrics and Gynecology, University of Hawaii, Honolulu, Hawaii., Chanock SJ; Division of Cancer Epidemiology and Genetics, NCI, NIH, Department of Health and Human Services, Bethesda, Maryland., Chen C; Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington., Chen XQ; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Chen Z; Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida., Cook LS; University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, New Mexico.; Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada., Cunningham JM; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota., De Vivo I; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., deFazio A; Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.; Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia., Doherty JA; Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, Utah., Dörk T; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., du Bois A; Department of Gynecology and Gynecologic Oncology, Ev. Kliniken Essen-Mitte (KEM), Essen, Germany.; Praxis für Humangenetik, Wiesbaden, Germany., Dunning AM; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Dürst M; Department of Gynaecology, Jena University Hospital- Friedrich Schiller University, Jena, Germany., Edwards T; Division of Epidemiology, Center for Human Genetics Research, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Edwards RP; Ovarian Cancer Center of Excellence, Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Ekici AB; Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Ewing A; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Fasching PA; Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.; David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California., Ferguson S; Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada., Flanagan JM; Division of Cancer and Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK., Fostira F; Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos,' Athens, Greece., Fountzilas G; Second Department of Medical Oncology, EUROMEDICA General Clinic of Thessaloniki, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece., Friedenreich CM; Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada., Gao B; Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.; The Crown Princess Mary Cancer Centre Westmead, Sydney-West Cancer Network, Westmead Hospital, Sydney, New South Wales, Australia., Gaudet MM; Department of Population Science, American Cancer Society, Atlanta, Georgia., Gawełko J; Institute of Nursing and Health Sciences, Medical Faculty, University of Rzeszów, Rzeszów, Poland., Gentry-Maharaj A; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Giles GG; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia., Glasspool R; Department of Medical Oncology, Beatson West of Scotland Cancer Centre and University of Glasgow, Glasgow, UK., Goodman MT; Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, California., Gronwald J; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Harris HR; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.; Department of Epidemiology, University of Washington, Seattle, Washington., Harter P; Department of Gynecology and Gynecologic Oncology, Ev. Kliniken Essen-Mitte (KEM), Essen, Germany., Hein A; Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany., Heitz F; Department of Gynecology and Gynecologic Oncology, Ev. Kliniken Essen-Mitte (KEM), Essen, Germany., Hildebrandt MAT; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas., Hillemanns P; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Høgdall E; Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.; Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark., Høgdall CK; The Juliane Marie Centre, Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Holliday EG; Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.; Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia., Huntsman DG; British Columbia's Ovarian Cancer Research (OVCARE) Program, BC Cancer, Vancouver General Hospital, and University of British Columbia, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC, Canada., Huzarski T; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.; Department of Genetics and Pathology, University of Zielona Góra, Zielona Góra, Poland., Jakubowska A; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.; Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland., Jensen A; Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark., Jones ME; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK., Karlan BY; David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, California., Karnezis A; Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, California., Kelley JL; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Khusnutdinova E; Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia.; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia., Killeen JL; Department of Pathology, Kapiolani Medical Center for Women and Children, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii., Kjaer SK; Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Klapdor R; Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany., Köbel M; Department of Pathology and Laboratory Medicine, University of Calgary, Foothills Medical Center, Calgary, Alberta, Canada., Konopka B; Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Konstantopoulou I; Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos,' Athens, Greece., Kopperud RK; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway., Koti M; Departments of Biomedical and Molecular Sciences and Obstetrics and Gynaecology, Cancer Biology and Genetics Division, Queen's Cancer Research Institute, Queen's University, Kingston, Ontario, Canada., Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Kupryjanczyk J; Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Lambrechts D; VIB Center for Cancer Biology, Leuven, Belgium.; Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium., Larson MC; Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota., Le Marchand L; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii., Lele S; Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York., Lester J; David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, California., Li AJ; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California., Liang D; College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas., Liebrich C; Clinics of Gynaecology, Cancer Center Wolfsburg, Wolfsburg, Germany., Lipworth L; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Lissowska J; Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center, Oncology Institute, Warsaw, Poland., Lu L; Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut., Lu KH; Department of Gynecologic Oncology and Clinical Cancer Genetics Program, University of Texas MD Anderson Cancer Center, Houston, Texas., Macciotta A; Evangelische Kliniken Essen-Mitte Klinik für Gynäkologie und gynäkologische Onkologie, Essen, Germany., Mattiello A; Dipertimento Di Medicina Clinca e Chirurgia, Federico II University, Naples, Italy., May T; Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada., McAlpine JN; British Columbia's Ovarian Cancer Research (OVCARE) Program-Gynecologic Tissue Bank, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver General Hospital and BC Cancer, Vancouver, BC, Canada., McGuire V; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California., McNeish IA; Division of Cancer and Ovarian Cancer Action Research Centre, Department Surgery and Cancer, Imperial College London, London, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Menon U; MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK., Modugno F; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Womens Cancer Research Center, Magee-Women's Research Institute and Hillman Cancer Center, Pittsburgh, Pennsylvania., Moysich KB; Division of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York., Nevanlinna H; Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Odunsi K; Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York., Olsson H; Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden., Orsulic S; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California., Osorio A; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain.; Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Palli D; Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy., Park-Simon TW; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Pearce CL; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan.; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California., Pejovic T; Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Permuth JB; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida., Podgorska A; Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Ramus SJ; School of Women's and Children's Health, Faculty of Medicine, University of NSW Sydney, Sydney, New South Wales, Australia.; Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, New South Wales, Australia., Rebbeck TR; Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Dana-Farber Cancer Institute, Boston, Massachusetts., Riggan MJ; Department of Gynecologic Oncology, Duke University Hospital, Durham, North Carolina., Risch HA; Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut., Rothstein JH; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York., Runnebaum IB; Department of Gynaecology, Jena University Hospital- Friedrich Schiller University, Jena, Germany., Scott RJ; Hunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.; Division of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia.; Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia., Sellers TA; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida., Senz J; British Columbia's Ovarian Cancer Research (OVCARE) Program, BC Cancer, Vancouver General Hospital, and University of British Columbia, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Setiawan VW; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California., Siddiqui N; Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK., Sieh W; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York., Spiewankiewicz B; Tytus Chałbiński Specialist Hospital in Radom, Warsaw, Poland., Sutphen R; Epidemiology Center, College of Medicine, University of South Florida, Tampa, Florida., Swerdlow AJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.; Division of Breast Cancer Research, The Institute of Cancer Research, London, UK., Szafron LM; Department of Immunology, the Maria Sklodowska-Curie Institute-Oncology Center, Warsaw, Poland., Teo SH; Breast Cancer Research Programme, Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Thompson PJ; Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, California., Thomsen LCV; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway., Titus L; Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire., Tone A; Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada., Tumino R; Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department for Gynecology with the Center for Oncologic Surgery Charité Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Berlin, Germany., Turman C; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Vanderstichele A; Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Edwards DV; Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Department of Biomedical Sciences, Women's Health Research, Vanderbilt University Medical Center, Nashville, Tennessee., Vergote I; Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Vierkant RA; Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota., Wang Z; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland., Wang-Gohrke S; Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany., Webb PM; Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., White E; Department of Epidemiology, University of Washington, Seattle, Washington.; Fred Hutchinson Cancer Research Center, Seattle, Washington., Whittemore AS; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California.; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, California., Winham SJ; Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota., Wu X; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas., Wu AH; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California., Yannoukakos D; Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos,' Athens, Greece., Spurdle AB; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., O'Mara TA; Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. tracy.omara@qimrberghofer.edu.au. |
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| Jazyk: | angličtina |
| Zdroj: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2021 Jan; Vol. 30 (1), pp. 217-228. Date of Electronic Publication: 2020 Nov 03. |
| DOI: | 10.1158/1055-9965.EPI-20-0739 |
| Abstrakt: | Background: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively, four of which overlap between the two cancers. We aimed to identify joint endometrial and ovarian cancer risk loci by performing a meta-analysis of GWAS summary statistics from these two cancers. Methods: Using LDScore regression, we explored the genetic correlation between endometrial cancer and ovarian cancer. To identify loci associated with the risk of both cancers, we implemented a pipeline of statistical genetic analyses (i.e., inverse-variance meta-analysis, colocalization, and M-values) and performed analyses stratified by subtype. Candidate target genes were then prioritized using functional genomic data. Results: Genetic correlation analysis revealed significant genetic correlation between the two cancers ( r Conclusions: Using cross-cancer GWAS meta-analysis, we have identified several joint endometrial and ovarian cancer risk loci and candidate target genes for future functional analysis. Impact: Our research highlights the shared genetic relationship between endometrial cancer and ovarian cancer. Further studies in larger sample sets are required to confirm our findings. (©2020 American Association for Cancer Research.) |
| Databáze: | MEDLINE |
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