| Autor: |
Calderón B; Instituto Tecnológico de Santo Domingo (INTEC), 10602 Santo Domingo, Dominican Republic.; Affinis, 10131 Santo Domingo, Dominican Republic., Gómez-Martín JM; Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria (IRyCIS), 28034 Madrid, Spain., Cuadrado-Ayuso M; Instituto Ramón y Cajal de Investigación Sanitaria (IRyCIS), 28034 Madrid, Spain.; Department of General and Digestive Surgery, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain., Cobeta P; Instituto Ramón y Cajal de Investigación Sanitaria (IRyCIS), 28034 Madrid, Spain.; Department of Anesthesiology, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain., Vega-Piñero B; Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria (IRyCIS), 28034 Madrid, Spain., Mateo R; Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria (IRyCIS), 28034 Madrid, Spain., Galindo J; Instituto Ramón y Cajal de Investigación Sanitaria (IRyCIS), 28034 Madrid, Spain.; Department of General and Digestive Surgery, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain., Botella-Carretero JI; Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria (IRyCIS), 28034 Madrid, Spain.; CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), 28034 Madrid, Spain. |
| Abstrakt: |
(1) Background: Inadequate levels of several trace elements and vitamins may impair spermatogenesis in men. Although weight loss after metabolic surgery normalizes male reproductive hormones, sperm quality seems to not improve. We hypothesized that circulating concentrations of zinc, copper and other trace elements and vitamins might be involved. (2) Methods: We studied 20 men submitted to metabolic surgery at baseline and after two years. Hormone profiles, serum trace elements and vitamins were studied together with sperm analysis. (3) Results: At follow-up, serum testosterone, follicle-stimulating hormone and inhibin B concentrations increased showing a beneficial hormonal response for spermatogenesis. Conversely, serum copper, zinc and ferritin showed a decline after surgery. In total, 33% of men showed zinc deficiency, 27% copper deficiency and 20% iron deficiency, among others. Sperm analysis showed that all revaluated patients had at least one abnormal parameter. Serum zinc concentrations showed a positive correlation with progressive motility (r = 0.577, p = 0.031), and serum ferritin a positive correlation with sperm volume (ρ = 0.535, p = 0.049). Serum copper showed a weak and near significant correlation with motility (r = 0.115, p = 0.051). (4) Conclusions: The lack of improvement in sperm quality in obese men after metabolic surgery may be related to nutrient malabsorption, especially zinc, copper and iron. |
