Chitosan-based nanoparticles against bacterial infections.

Autor: Rashki S; Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran., Asgarpour K; Department of Medicine, University of Western Ontario, London, Ontario, Canada., Tarrahimofrad H; Department of Animal Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran., Hashemipour M; School of Medicine, Kashan University of Medical Sciences, Kashan, Iran., Ebrahimi MS; School of Medicine, Kashan University of Medical Sciences, Kashan, Iran., Fathizadeh H; Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran., Khorshidi A; Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran., Khan H; Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, Pakistan., Marzhoseyni Z; Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran., Salavati-Niasari M; Institute of Nano Science and Nano Technology, University of Kashan, Kashan, Iran. Electronic address: salavati@kashanu.ac.ir., Mirzaei H; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: h.mirzaei2002@gmail.com.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2021 Jan 01; Vol. 251, pp. 117108. Date of Electronic Publication: 2020 Sep 20.
DOI: 10.1016/j.carbpol.2020.117108
Abstrakt: Chitosan nanomaterials have become a hot topic in biomedicine due to exerting antimicrobial effects with interestingly high levels of biodegradability and biocompatibility without causing toxicity. Regarded as a potential means of wound dressing with antimicrobial activity, chitosan exhibits higher efficiency when it is functionally modified with other natural compounds, metallic antimicrobial particles and antibiotics. Mechanistically, the antibacterial effect of chitosan is mostly, associated with the death-proceeding leakage of intracellular content, induced by malfunction and altered permeability of the negatively charged cell membrane, on which chitosan is adsorbed. Moreover, chitosan nanoparticles (NPs) are endowed with favorable features of NPs (i.e., large surface-to-volume ratio, high functionalization possibilities and a greater capacity for drug loading), as well as that of their chitosan base, thereby possessing strengthened antibacterial potential. In addition, polycations target negatively charged bacterial membranes, so bacteria cells are more strongly affected by polycationic chitosan NPs than pure chitosan.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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