An estimation of patients at potential risk for drug-induced sexual dysfunction using pharmacy dispensing data.

Autor:	Gordijn R; Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Nicolai MPJ; Department of Urology, Haga Hospital, The Hague, The Netherlands., Elzevier HW; Department of Urology and Department of Medical Decision Making., Guchelaar HJ; Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Teichert M; Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.
Jazyk:	angličtina
Zdroj:	Family practice [Fam Pract] 2021 Jun 17; Vol. 38 (3), pp. 292-298.
DOI:	10.1093/fampra/cmaa116
Abstrakt:	Background and Objectives: Adverse drug reactions on sexual functioning (sADRs) may seriously decrease a person's quality of life. A multitude of diseases and drugs are known risk factors for sexual dysfunction. To inform patients better about these potential effects, more insight is needed on the estimated number of patients at high risk for sADRs and their characteristics. Methods: This cross-sectional study estimated the number of patients in the Netherlands who were dispensed drugs with a potential very high risk (>10%) or high risk (1-10%) for sADRs as registered in the Summary of Product Characteristics, the official drug information text in Europe. Results: In April 2019, 2.06% of the inhabitants of the Netherlands received drugs with >10% risk for sADRs and 7.76% with 1-10% risk. The majority of these patients had at least one additional risk factor for decreased sexual function such as high age or depression. Almost half of the patients were identified with two or more morbidities influencing sexual functioning. Paroxetine, sertraline and spironolactone were the most dispensed drugs with a potential >10% risk for sADRs. One-third of their first dispenses were not followed by a second dispense, with a higher risk of discontinuation for a decreasing number of morbidities. Conclusion: About 1 in 11 inhabitants of the Netherlands was dispensed a drug with a potential high risk for sADRs, often with other risk factors for sexual complaints. Further research is needed whether these users actually experience sADRs, to understand its impact on multimorbid patients and to provide alternatives if needed. (© The Author(s) 2020. Published by Oxford University Press.)
Databáze:	MEDLINE
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