Nano-targeting lessons from the SARS-CoV-2.

Autor: Ribeiro IRS; Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), 13083-970, Campinas, Brazil.; Institute of Chemistry (IQ), University of Campinas (UNICAMP), 13083-970, Post Office Box 6154, Campinas, SP, Brazil., da Silva RF; Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), 13083-970, Campinas, Brazil., Silveira CP; Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), 13083-970, Campinas, Brazil., Galdino FE; Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), 13083-970, Campinas, Brazil.; Institute of Chemistry (IQ), University of Campinas (UNICAMP), 13083-970, Post Office Box 6154, Campinas, SP, Brazil., Cardoso MB; Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), 13083-970, Campinas, Brazil.; Institute of Chemistry (IQ), University of Campinas (UNICAMP), 13083-970, Post Office Box 6154, Campinas, SP, Brazil.
Jazyk: angličtina
Zdroj: Nano today [Nano Today] 2021 Feb; Vol. 36, pp. 101012. Date of Electronic Publication: 2020 Oct 23.
DOI: 10.1016/j.nantod.2020.101012
Abstrakt: The lack of targeting efficacy has frequently led functionalized nanoparticles to accumulate in unwanted cells and tissues while boosting toxicity-related effects. Conversely, viruses are natural nanoparticles that precisely and responsively interact with the biological machinery through an effective-driven fashion. This interaction is enhanced by a meticulous spatial arrangement which results in a quasi-crystalline distribution of proteins on the viruses' surface. Amidst the COVID-19 pandemic, we propose to look at the SARS-CoV-2 nanoscale viral scaffold as an example of a highly-ordered architecture that must inspire and tailor the production of targeted synthetic nanoparticles.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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