Probiotic supplementation in marathonists and its impact on lymphocyte population and function after a marathon: a randomized placebo-controlled double-blind study.

Autor: Batatinha H; Immunometabolism Research Group, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP, Brazil. batatinha.helena@usp.br.; Department of Cell and Developmental Biology, University of São Paulo,, 1524, Prof Lineu Prestes Av., Sao Paulo, SP, 05508-000, Brazil. batatinha.helena@usp.br., Tavares-Silva E; Programa de pós-graduação em psicobiologia, Universidade Federal de São Paulo, Santos, Brazil., Leite GSF; Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, São Paulo, Brazil., Resende AS; Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, São Paulo, Brazil., Albuquerque JAT; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Arslanian C; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Fock RA; Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Lancha AH Jr; Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, São Paulo, Brazil., Lira FS; Exercise and Immunometabolism Research Group, Post-Graduation Program in Movement Sciences, Department of Physical Education, Universidade Estadual Paulista (UNESP), School of Technology and Sciences, Presidente Prudente, Brazil., Krüger K; Department of Exercise Physiology and Sports Therapy, Justus-Liebig-University Giessen, Giessen, Germany., Thomatieli-Santos R; Programa de pós-graduação em psicobiologia, Universidade Federal de São Paulo, Santos, Brazil.; Department of Bioscience, Universidade Federal de São Paulo, Santos, Brazil., Rosa-Neto JC; Immunometabolism Research Group, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2020 Nov 02; Vol. 10 (1), pp. 18777. Date of Electronic Publication: 2020 Nov 02.
DOI: 10.1038/s41598-020-75464-0
Abstrakt: Probiotic supplementation arises as playing an immune-stimulatory role. High-intensity and -volume exercise can inhibit immune cell function, which threatens athletic performance and recovery. We hypothesized that 30 days of probiotic supplementation could stabilize the immune system of athletes preventing immune suppression after a marathon race. Twenty-seven male marathonists were double-blinded randomly into probiotic (Bifidobacterium-animalis-subsp.-Lactis (10 × 10 9 ) and Lactobacillus-Acidophilus (10 × 10 9 ) + 5 g of maltodextrin) and placebo (5 g of maltodextrin) group. They received 30 sachets and supplemented 1 portion/day during 30 days before the race. Blood were collected 30 days before (rest), 1 day before (pre), 1 h after (post) and 5 days after the race (recovery). Both chronic and acute exercise modulated a different T lymphocyte population (CD3 + CD4 - CD8 - T-cells), increasing pre-race, decreasing post and returning to rest values at the recovery. The total number of CD8 T cell and the memory subsets statistically decreased only in the placebo group post-race. Pro-inflammatory cytokine production by stimulated lymphocytes decreased in the probiotic group after the supplementation period. 30 days of probiotic supplementation maintained CD8 T cell and effector memory cell population and played an immunomodulatory role in stimulated lymphocytes. Both, training and marathon modulated a non-classical lymphocyte population regardless of probiotic supplementation.
Databáze: MEDLINE
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