Effect of early time-restricted feeding on the metabolic profile of adults with excess weight: A systematic review with meta-analysis.

Autor: Pureza IROM; Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, Brazil., Macena ML; Faculdade de Nutrição (FANUT), Universidade Federal de Alagoas (UFAL), Campus AC Simões, 57072-900, Cidade Universitária, Maceió, Alagoas, Brazil., da Silva Junior AE; Faculdade de Nutrição (FANUT), Universidade Federal de Alagoas (UFAL), Campus AC Simões, 57072-900, Cidade Universitária, Maceió, Alagoas, Brazil., Praxedes DRS; Faculdade de Nutrição (FANUT), Universidade Federal de Alagoas (UFAL), Campus AC Simões, 57072-900, Cidade Universitária, Maceió, Alagoas, Brazil., Vasconcelos LGL; Faculdade de Nutrição (FANUT), Universidade Federal de Alagoas (UFAL), Campus AC Simões, 57072-900, Cidade Universitária, Maceió, Alagoas, Brazil., Bueno NB; Faculdade de Nutrição (FANUT), Universidade Federal de Alagoas (UFAL), Campus AC Simões, 57072-900, Cidade Universitária, Maceió, Alagoas, Brazil. Electronic address: nassib.bueno@fanut.ufal.br.
Jazyk: angličtina
Zdroj: Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2021 Apr; Vol. 40 (4), pp. 1788-1799. Date of Electronic Publication: 2020 Oct 23.
DOI: 10.1016/j.clnu.2020.10.031
Abstrakt: Background & Aims: Time-restricted feeding (TRF) studies have been summarized in previous systematic reviews, but these were not specific for individuals with excess weight and studies involving early time-restricted feeding (eTRF). This meta-analysis aimed to evaluate the effect of eTRF on the metabolic profile of adults with excess weight.
Methods: Data were extracted from MEDLINE, CENTRAL, LILACS, Web of Science, ClinicalTrials.gov, OpenGrey.eu, Greylit, and by manual search. Randomized controlled trials in which the participants were older than 18 years, with a body mass index greater than 25 kg/m 2 and that were allocated in an intervention with eTRF were included. The studies should have assessed any of the following outcomes from the metabolic profile: resting metabolic rate, triacylglycerol, total cholesterol, HDL-cholesterol, and LDL-cholesterol, fasting blood glucose, insulin, HOMA-IR, C-reactive protein, Interleukin-6, cortisol, leptin, Ghrelin, Peptide YY and glucagon-like peptide, hemodynamic parameters, and appetite. The risk of bias was assessed using the Cochrane collaboration tool. Publication bias was examined with a funnel plot and Egger's test. GRADE was used to assess the overall quality of evidence.
Results: Ten articles from nine randomized clinical trials, with 264 individuals, were included in qualitative analysis and eight articles with 184 individuals were included in the meta-analysis. There were significant effects on the fasting blood glucose (WMD: -2.75; 95% CI [-4.59; -0.90] mg/dL; p < 0.01; I 2  = 88.7%; 7 studies) and HOMA-IR. (WMD: -0.50; 95% CI [-0.82; -0.19]; p < 0.01; I 2  = 50.8%; 4 studies). The other outcomes were not significant. Three studies showed a high risk of bias. Seven outcomes were classified as very low quality and one as low quality. There was evidence of publication bias for fasting blood glucose.
Conclusions: Although the eTRF regimen seems to have a beneficial effect on the fasting blood glucose and HOMA-IR of individuals with excess weight, the results of this meta-analysis should be analyzed with caution due to the low-quality evidence.
Competing Interests: Conflict of interest The authors declare no conflicts of interests.
(Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: