XIAP's Profile in Human Cancer.
Autor: | Tu H; Department of Environmental Medicine, New York University, Grossman School of Medicine, NY 10010, USA., Costa M; Department of Environmental Medicine, New York University, Grossman School of Medicine, NY 10010, USA. |
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Jazyk: | angličtina |
Zdroj: | Biomolecules [Biomolecules] 2020 Oct 29; Vol. 10 (11). Date of Electronic Publication: 2020 Oct 29. |
DOI: | 10.3390/biom10111493 |
Abstrakt: | XIAP, the X-linked inhibitor of apoptosis protein, regulates cell death signaling pathways through binding and inhibiting caspases. Mounting experimental research associated with XIAP has shown it to be a master regulator of cell death not only in apoptosis, but also in autophagy and necroptosis. As a vital decider on cell survival, XIAP is involved in the regulation of cancer initiation, promotion and progression. XIAP up-regulation occurs in many human diseases, resulting in a series of undesired effects such as raising the cellular tolerance to genetic lesions, inflammation and cytotoxicity. Hence, anti-tumor drugs targeting XIAP have become an important focus for cancer therapy research. RNA-XIAP interaction is a focus, which has enriched the general profile of XIAP regulation in human cancer. In this review, the basic functions of XIAP, its regulatory role in cancer, anti-XIAP drugs and recent findings about RNA-XIAP interactions are discussed. Competing Interests: The authors declare no conflict of interest. |
Databáze: | MEDLINE |
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