XIAP's Profile in Human Cancer.

Autor: Tu H; Department of Environmental Medicine, New York University, Grossman School of Medicine, NY 10010, USA., Costa M; Department of Environmental Medicine, New York University, Grossman School of Medicine, NY 10010, USA.
Jazyk: angličtina
Zdroj: Biomolecules [Biomolecules] 2020 Oct 29; Vol. 10 (11). Date of Electronic Publication: 2020 Oct 29.
DOI: 10.3390/biom10111493
Abstrakt: XIAP, the X-linked inhibitor of apoptosis protein, regulates cell death signaling pathways through binding and inhibiting caspases. Mounting experimental research associated with XIAP has shown it to be a master regulator of cell death not only in apoptosis, but also in autophagy and necroptosis. As a vital decider on cell survival, XIAP is involved in the regulation of cancer initiation, promotion and progression. XIAP up-regulation occurs in many human diseases, resulting in a series of undesired effects such as raising the cellular tolerance to genetic lesions, inflammation and cytotoxicity. Hence, anti-tumor drugs targeting XIAP have become an important focus for cancer therapy research. RNA-XIAP interaction is a focus, which has enriched the general profile of XIAP regulation in human cancer. In this review, the basic functions of XIAP, its regulatory role in cancer, anti-XIAP drugs and recent findings about RNA-XIAP interactions are discussed.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje