The role of MRI in applying the 3Rs to non-human primate neuroscience.

Autor: Prescott MJ; National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), Gibbs Building, 215 Euston Road, London NW1 2BE, UK. Electronic address: mark.prescott@nc3rs.org.uk., Poirier C; Biosciences Institute & Centre for Behaviour and Evolution, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address: colline.poirier@ncl.ac.uk.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2021 Jan 15; Vol. 225, pp. 117521. Date of Electronic Publication: 2020 Nov 01.
DOI: 10.1016/j.neuroimage.2020.117521
Abstrakt: Magnetic resonance imaging is playing a significant role in applying the 3Rs to neuroscience studies using non-human primates. MRI scans are contributing to refinement by enhancing the selection and assignment of animals, guiding the manufacture of custom-fitted recording and head fixation devices, and assisting with the diagnosis of health issues and their treatment. MRI is also being used to better understand the impact of neuroscience procedures on the welfare of NHPs. MRI has helped to optimise NHP use and make greater scientific progress than would otherwise be made using larger numbers of animals. Whilst human fMRI studies have replaced some NHP studies, their potential to directly replace NHP electrophysiology is limited at present. Given the considerable advantages of MRI for electrophysiology experiments, including improved welfare of NHPs, consideration should be given to focusing NHP electrophysiology laboratories around MRI facilities. Greater sharing of MRI data sets, and improvements in MRI contrast and resolution, are expected to further advance the 3Rs in the future.
Competing Interests: Declaration of Competing Interest The authors declare no competing interests.
(Copyright © 2020. Published by Elsevier Inc.)
Databáze: MEDLINE
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