| Autor: |
Levine SM; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University , Mannheim, Germany.; Department of Psychiatry and Psychotherapy, University of Regensburg , Regensburg, Germany., Kumpf M; Department of Psychiatry and Psychotherapy, University of Regensburg , Regensburg, Germany., Rupprecht R; Department of Psychiatry and Psychotherapy, University of Regensburg , Regensburg, Germany., Schwarzbach JV; Department of Psychiatry and Psychotherapy, University of Regensburg , Regensburg, Germany. |
| Jazyk: |
angličtina |
| Zdroj: |
Cognitive neuroscience [Cogn Neurosci] 2021 Jan; Vol. 12 (1), pp. 28-39. Date of Electronic Publication: 2020 Nov 01. |
| DOI: |
10.1080/17588928.2020.1839039 |
| Abstrakt: |
Fear-generalization is a critical function for survival, in which an organism extracts information from a specific instantiation of a threat (e.g., the western diamondback rattlesnake in my front yard on Sunday) and learns to fear - and accordingly respond to - pertinent higher-order information (e.g., snakes live in my yard). Previous work investigating fear-conditioning in humans has used functional magnetic resonance imaging (fMRI) to demonstrate that activity patterns representing stimuli from an aversively-conditioned category (CS+) are more similar to each other than those of a neutral category (CS-). Here we used fMRI and multiple aversively-conditioned categories to ask whether we would find only similarity increases within the CS+ categories or also similarity increases between the CS+ categories. Using representational similarity analysis, we correlated several models to activity patterns underlying different brain regions and found that, following fear-conditioning, between-category and within-category similarity increased for the CS+ categories in the insula, superior frontal gyrus (SFG), and the right temporal pole. When specifically investigating fear- generalization , these between- and within-category effects were detected in the SFG. These results advance prior pattern-based neuroimaging work by exploring the effect of aversively-conditioning multiple categories and indicate an extended role for such regions in potentially representing supracategorical information during fear-learning. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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