Toxic Epidermal Necrolysis (TEN)/Stevens-Johnson Syndrome (SJS) Epidemiology and Mortality Rate at King Fahad Specialist Hospital (KFSH) in Qassim Region of Saudi Arabia: A Retrospective Study.

Autor: Alajaji A; Qassim University, College of Medicine, Buraydah, Saudi Arabia., Chandra Shekaran J; Ministry of Health, KFSH, Dammam, Saudi Arabia., Mohammed Aldhabbah O; Qassim University, College of Medicine, Buraydah, Saudi Arabia., Alhindi HA; Qassim University, College of Medicine, Buraydah, Saudi Arabia., Almazyad NS; Qassim University, College of Medicine, Buraydah, Saudi Arabia., Aljutayli ZA; Qassim University, College of Medicine, Buraydah, Saudi Arabia., Abaalkhail S; Ministry of Health, KFSH, Dammam, Saudi Arabia., Alfouzan S; Ministry of Health, KFSH, Dammam, Saudi Arabia.
Jazyk: angličtina
Zdroj: Dermatology research and practice [Dermatol Res Pract] 2020 Oct 09; Vol. 2020, pp. 7524726. Date of Electronic Publication: 2020 Oct 09 (Print Publication: 2020).
DOI: 10.1155/2020/7524726
Abstrakt: Background: Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening conditions caused by drug reactions. There are multiple causative drugs and different risk factors associated with SJS/TEN.
Objectives: To study the epidemiology of SJS/TEN and associated mortality rate in Qassim region, Saudi Arabia. Methodology . A retrospective chart review of all patients with the diagnosis of SJS/TEN who were admitted to King Fahad Specialist Hospital (KFSH) in Qassim region, Saudi Arabia, for the period between Jan 2014 to Jan 2019. The Careware information health system is used at KFSH, and patients were identified searching the diagnosis SJS/TEN.
Results: Total of 10 patients with diagnosis of SJS/TEN were admitted to KFSH for the period from Jan 2014 to Jan 2019. Antibiotics were the culprit in 5 out of 10 patients. 9 out of 10 patients survived with good outcome. One patient with the diagnosis of TEN died, given extensive skin involvement complicated by sepsis.
Conclusion: Despite the limitation of this study given small sample size, this is the first study of its kind that discusses the epidemiology of SJS/TEN in Saudi Arabia. We found the estimated incidence rate of SJS/TEN in Qassim region to be 7.6 cases per million person-years. Antibiotics and antiepileptics were the culprits in 8 out of 10 patients.
Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this paper.
(Copyright © 2020 Abdullah Alajaji et al.)
Databáze: MEDLINE
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