Association between women's age and stage, morphology, and implantation of the competent blastocyst: a multicenter cohort study.

Autor:	Borgstrøm MB; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital Herlev, Herlev & Aalborg University, Copenhagen, Denmark. Electronic address: maria.borgstroem@regionh.dk., Grøndahl ML; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital Herlev, Herlev, Denmark., Klausen TW; Department of Hematology, Copenhagen University Hospital Herlev, Herlev, Denmark., Danielsen AK; Department of Gastroenterology, Copenhagen University Hospital Herlev, Herlev & University of Copenhagen, Copenhagen, Denmark., Thomsen T; Department of Anaesthesiology, Copenhagen University Hospital Herlev, Herlev & University of Copenhagen, Copenhagen, Denmark., Gabrielsen A; The Fertility Clinic, Horsens Regional Hospital, Horsens, Denmark., Zedeler A; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Povlsen BB; The Fertility Clinic, Skive Regional Hospital, Skive, Denmark., Hnida C; The Fertility Unit, Aalborg University Hospital, Aalborg, Denmark., Almind GJ; Copenhagen Fertility Center, Copenhagen, Denmark., Fedder J; The Fertility Clinic, Odense University Hospital, Odense, Denmark., Kirk J; Maigaard Fertility Clinic, Aarhus N., Denmark., Hindkjær J; Aagaard Fertility Clinic, Aarhus N., Denmark., Lemmen JG; Vitanova Fertility Center, Copenhagen, Denmark., Petersen K; VivaNeo Ciconia Fertility Clinic, Højbjerg, Denmark., Haahr K; Stork IVF Clinic, Copenhagen, Denmark., Petersen MR; Department of Obstetrics and Gynecology, The Fertility Clinic, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Laursen S; The Fertility Clinic IVF-syd, Fredericia, Denmark., Hansen TH; The Fertility Clinic, Zealand University Hospital Køge, Køge, Denmark., Knudsen UB; The Fertility Clinic at Horsens Regional Hospital & Aarhus University, Horsens, Denmark., Bentin-Ley U; The Danish Fertility Clinic, Frederiksberg C., Denmark., Larsen T; Danish Medical Data Center, Vallensbæk, Denmark., Kesmodel US; The Fertility Unit, Aalborg University Hospital & Aalborg University, Aalborg, Denmark.
Jazyk:	angličtina
Zdroj:	Fertility and sterility [Fertil Steril] 2021 Mar; Vol. 115 (3), pp. 646-654. Date of Electronic Publication: 2020 Oct 29.
DOI:	10.1016/j.fertnstert.2020.08.1432
Abstrakt:	Objective: To study if the age of women undergoing assisted reproductive technology treatment associates with stage, morphology, and implantation of the competent blastocyst. Design: Multicenter historical cohort study based on exposure (age) and outcome data (blastocyst stage and morphology and initial human chorionic gonadotrophin [hCG] rise) from women undergoing single blastocyst transfer resulting in singleton pregnancy/birth. Setting: Sixteen private and university-based facilities. Patient(s): In this study, 7,246 women who, between 2014 and 2018, underwent controlled ovarian stimulation (COS) or frozen-thawed embryo transfer (FET) with a single blastocyst transfer resulting in singleton pregnancy were identified. Linking data to the Danish Medical Birth Registry resulted in a total of 4,842 women with a live birth being included. Intervention(s): None. Main Outcome Measure(s): The competent blastocyst development stage (1-6), inner cell mass (A, B, C), trophectoderm (A, B, C), and initial serum hCG value. Result(s): Adjusted analysis of age and stage in COS treatments showed that for every 1-year increase in age there was a 5% reduced probability of the competent blastocyst assessed as being in a high stage at transfer. Comparison between hCG values in women 18-24 years and 25-29 years in both COS and FET showed significantly lower levels in the youngest women. Conclusion(s): The initial hCG rise was influenced by the age of the woman, with an identical pattern for hCG values in COS and FET treatments. In COS, the competent blastocyst had a reduced stage with increasing women's age. (Copyright © 2020 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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