| Autor: |
Weil AG; 1Division of Pediatric Neurosurgery, Department of Surgery, Sainte-Justine Hospital, Montreal., Mathews N; 2Departments of Pediatrics and Human Genetics, McGill University and McGill University Health Centre, Montreal., Farmer JP; 3Division of Neurosurgery, Department of Pediatric Surgery, Montreal Children's Hospital, McGill University Health Centre, Montreal., St Martin C; Departments of4Radiology and., Albrecht S; 5Pathology, Montreal Children's Hospital, Montreal; and., Jabado N; 6Departments of Pediatrics and Human Genetics, Montreal Children's Hospital, McGill University and McGill University Health Centre, Montreal, Quebec, Canada., Dudley RWR; 3Division of Neurosurgery, Department of Pediatric Surgery, Montreal Children's Hospital, McGill University Health Centre, Montreal. |
| Abstrakt: |
Here, the authors present 2 cases of nongerminomatous germ cell tumor (NGGCT): a neonate with a mixed malignant germ cell tumor, 5% yolk sac tumor (YST) and 95% immature teratoma components, originating from the right mesial temporal lobe; and a 2-month-old infant with a pure YST originating from the left middle cranial fossa. These tumors with yolk sac components, which are thought to have a poor prognosis, were successfully treated with complete tumor resection alone and subtotal tumor resection with chemotherapy, respectively. Event-free survival exceeds 5 years for each patient even though neither received radiotherapy. The authors highlight the role of radical surgery and the successful treatment of neonatal YST with aggressive resection (and chemotherapy in 1 case) while avoiding radiation therapy. They also report the very rare non-midline location of these neonatal NGGCTs and emphasize the importance of considering YSTs and mixed NGGCTs with YST components in the differential diagnosis of non-midline hemispheric or skull base tumors in newborns. |
