Physical and sexual abuse in childhood and adolescence and leukocyte telomere length: A pooled analysis of the study on psychosocial stress, spirituality, and health.

Autor: Warner ET; MGH/Harvard Center on Genomics, Vulnerable Populations, and Health Disparities, Mongan Institute, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Medicine, Clinical Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Zhang Y; MGH/Harvard Center on Genomics, Vulnerable Populations, and Health Disparities, Mongan Institute, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America., Gu Y; MGH/Harvard Center on Genomics, Vulnerable Populations, and Health Disparities, Mongan Institute, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Taporoski TP; Department of Neurology (Sleep Medicine), Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.; Laboratory of Genetics and Molecular Cardiology, Heart Institute (Incor), University of São Paulo Medical School, São Paulo, São Paulo, Brazil., Pereira A; Laboratory of Genetics and Molecular Cardiology, Heart Institute (Incor), University of São Paulo Medical School, São Paulo, São Paulo, Brazil., DeVivo I; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Spence ND; MGH/Harvard Center on Genomics, Vulnerable Populations, and Health Disparities, Mongan Institute, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Sociology, University of Toronto, Toronto, Ontario, Canada., Cozier Y; Slone Epidemiology Center, Boston University, Boston, Massachusetts, United States of America., Palmer JR; Slone Epidemiology Center, Boston University, Boston, Massachusetts, United States of America., Kanaya AM; Division of General Internal Medicine, University of California San Francisco, San Francisco, Califonia, United States of America., Kandula NR; Department of Medicine, Northwestern University, Evanston, Illinois, United States of America., Cole SA; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America., Tworoger S; Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America., Shields A; MGH/Harvard Center on Genomics, Vulnerable Populations, and Health Disparities, Mongan Institute, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Oct 30; Vol. 15 (10), pp. e0241363. Date of Electronic Publication: 2020 Oct 30 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0241363
Abstrakt: Introduction: We examined whether abuse in childhood and/or adolescence was associated with shorter telomere length in a pooled analysis of 3,232 participants from five diverse cohorts. We also assessed whether religion or spirituality (R/S) could buffer deleterious effects of abuse.
Methods: Physical and sexual abuse in childhood (age <12) and adolescence (age 12-18) was assessed using the Revised Conflict Tactics Scale and questions from a 1995 Gallup survey. We measured relative leukocyte telomere lengths (RTL) using quantitative real time polymerase chain reaction. We used generalized estimating equations to assess associations of physical and sexual abuse with log-transformed RTL z-scores. Analyses were conducted in each cohort, overall, and stratified by extent of religiosity or spirituality and religious coping in adulthood. We pooled study-specific estimates using random-effects models and assessed between-study heterogeneity.
Results: Compared to no abuse, severe sexual abuse was associated with lower RTL z-scores, in childhood: -15.6%, 95% CI: -25.9, -4.9; p-trend = 0.04; p-heterogeneity = 0.58 and in adolescence: -16.5%, 95% CI: -28.1, -3.0; p-trend = 0.08; p-heterogeneity = 0.68. Sexual abuse experienced in both childhood and adolescence was associated with 11.3% lower RTL z-scores after adjustment for childhood and demographic covariates (95% CI: -20.5%, -2.0%; p-trend = 0.03; p-heterogeneity = 0.62). There was no evidence of effect modification by R/S. Physical abuse was not associated with telomere length.
Conclusions: Sexual abuse in childhood or adolescence was associated with a marker of accelerated biological aging, decreased telomere length. The lack of moderation by R/S may be due to inability to capture the appropriate time period for those beliefs and practices.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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