A cohort study of personal and family history of skin cancer in relation to all-cause and cancer-specific mortality.

Autor: Small J; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, 29425, USA., Wallace K; Department of Public Health Sciences, Medical University of South Carolina, BE 103, 68 President Street, Charleston, SC, 29425, USA. wallack@musc.edu., Hill EG; Department of Public Health Sciences, Medical University of South Carolina, 86 Jonathan Lucas St, Charleston, SC, 29425, USA., Thiers BH; Dermatology and Dermatologic Surgery, Medical University of South Carolina, 135 Rutledge Ave, Charleston, SC, 29425, USA., Leach BC; The Skin Surgery Center of Charleston, 180 Wingo Way, Mount Pleasant, SC, 29464, USA., Alberg AJ; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Discovery I, 915 Greene Street, Columbia, SC, 29201, USA.
Jazyk: angličtina
Zdroj: Cancer causes & control : CCC [Cancer Causes Control] 2021 Jan; Vol. 32 (1), pp. 75-82. Date of Electronic Publication: 2020 Oct 29.
DOI: 10.1007/s10552-020-01359-0
Abstrakt: Purpose: Even though the fatality rate from skin cancers is low, evidence from a few cohort studies has raised the possibility that people with a personal history of skin cancer may have a higher all-cause mortality rate compared with those without a personal history of skin cancer. The purpose of the present study was to investigate the potential links between a personal history or family history of skin cancer and all-cause and cancer-specific mortality METHODS: A prospective cohort (n = 8,622) was assembled within the NHANES I follow-up study. Cox Proportional Hazard Regression analysis was used to estimate the hazard ratios (HR) and 95% confidence intervals (CI) for the association for personal and family history of skin cancer and all-cause and cancer-specific mortality.
Results: After adjustment for several potential confounding variables, a personal history of skin cancer was associated with decreased risk for all-cause mortality (HR 0.72, 95% CI 0.61-0.85), whereas the results for cancer-specific mortality were consistent with a null association (HR 0.97, 95% CI 0.74-1.27). A family history of skin cancer was not significantly associated with all-cause mortality (HR 0.97, 95% CI 0.76-1.24) or cancer-specific mortality (HR 0.69, 95% CI 0.38-1.24).
Conclusion: The results of the present study do not support the hypothesis that a personal history or family history of skin cancer is associated with an increased risk of all-cause or cancer-specific mortality. The high prevalence of skin cancer adds to the public health significance of this question, providing a strong rationale for further research to resolve this question.
Databáze: MEDLINE
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