Localized and triggered release of oxaliplatin for the treatment of colorectal liver metastasis.
Autor: | Gogineni VR; Departments of Radiology & Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI., Maddirela DR; Departments of Radiology & Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI., Park W; Department of Radiology, Northwestern University, Chicago, IL., Jagtap JM; Departments of Radiology & Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI., Parchur AK; Departments of Radiology & Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI., Sharma G; Departments of Radiology & Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI., Ibrahim ES; Departments of Radiology & Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI., Joshi A; Departments of Radiology & Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI., Larson AC; Department of Radiology, Northwestern University, Chicago, IL., Kim DH; Department of Radiology, Northwestern University, Chicago, IL., White SB; Departments of Radiology & Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI. |
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Jazyk: | angličtina |
Zdroj: | Journal of Cancer [J Cancer] 2020 Oct 12; Vol. 11 (23), pp. 6982-6991. Date of Electronic Publication: 2020 Oct 12 (Print Publication: 2020). |
DOI: | 10.7150/jca.48528 |
Abstrakt: | Purpose: The aim of this study was to develop and evaluate a liposome formulation that deliver oxaliplatin under magnetic field stimulus in high concentration to alleviate the off-target effects in a rat model of colorectal liver metastases (CRLM). Materials and Methods: Hybrid liposome-magnetic nanoparticles loaded with Cy5.5 dye and oxaliplatin (L-NIR- Fe Competing Interests: Competing Interests: The authors have declared that no competing interest exists. (© The author(s).) |
Databáze: | MEDLINE |
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