Autonomic dysfunctions in multiple sclerosis: Challenges of clinical practice (Review).

Autor: Sirbu CA; Department of Preclinical Disciplines, Faculty of Medicine, 'Titu Maiorescu' University, 031593 Bucharest, Romania.; Department of Neurology, Central Military Emergency University Hospital, 010242 Bucharest, Romania., Mezei RM; Department of Neurology, Central Military Emergency University Hospital, 010242 Bucharest, Romania., Falup-Pecurariu C; Department of Neurology, County Emergency Clinic Hospital, 500365 Brasov, Romania.; Department of Neurology, Faculty of Medicine, Transilvania University, 500036 Brașov, Romania., Bratu OG; Department of Urology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Urology, Central Military Emergency University Hospital, 010242 Bucharest, Romania., Sirbu AM; Department of Endocrinology, 'C. I. Parhon' National Institute of Endocrinology, 011863 Bucharest, Romania., Ghinescu MC; Department of Preclinical Disciplines, Faculty of Medicine, 'Titu Maiorescu' University, 031593 Bucharest, Romania., Radu FI; Department of Preclinical Disciplines, Faculty of Medicine, 'Titu Maiorescu' University, 031593 Bucharest, Romania.; Department of Gastroenterology, Central Military Emergency University Hospital, 010242 Bucharest, Romania.
Jazyk: angličtina
Zdroj: Experimental and therapeutic medicine [Exp Ther Med] 2020 Dec; Vol. 20 (6), pp. 196. Date of Electronic Publication: 2020 Oct 14.
DOI: 10.3892/etm.2020.9326
Abstrakt: Multiple sclerosis, demyelinating, inflammatory, degenerative, and chronic disease, raises many challenges in terms of disease management. The autonomic nervous system is affected by neuroinflammation but also contributes to its maintenance and the evolution of the disease. Multiple sclerosis interfering with parasympathetic or sympathetic modulation may influence the immune response. Less attention is paid to autonomic dysfunctions, although they produce a serious impact on the quality of life. In addition to motor disabilities, patients also have non-motor dysfunctions. Regardless of its clinical forms, patients with multiple sclerosis may have autonomous disturbances such as bladder, sexual, cardiovascular, thermoregulatory, gastrointestinal dysfunction and fatigue. These must be identified based on medical history, clinical symptoms, and specific paraclinical tests. In addition to the multitude of immunomodulatory therapeutic agents that influence the progression of the disease, the therapy of autonomic dysfunctions remains difficult to address. However, their identification and treatment lead to increased quality of patient management and avoid complications of this disease.
(Copyright © 2020, Spandidos Publications.)
Databáze: MEDLINE
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