Cystatin C and uncontrolled hypertension.
| Autor: | Omaygenç MO; Department of Cardiology, Faculty of Medicine, İstanbul Medipol University; İstanbul-Turkey., Özcan ÖU; Department of Cardiology, Faculty of Medicine, İstanbul Medipol University; İstanbul-Turkey., Çakal B; Department of Cardiology, Faculty of Medicine, İstanbul Medipol University; İstanbul-Turkey., Karaca O; Department of Cardiology, Faculty of Medicine, İstanbul Medipol University; İstanbul-Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Anatolian journal of cardiology [Anatol J Cardiol] 2020 Nov; Vol. 24 (5), pp. 309-315. |
| DOI: | 10.14744/AnatolJCardiol.2020.78974 |
| Abstrakt: | Objective: Increased serum level of cystatin C, a sensitive biomarker for renal function, seems to predict adverse cardiovascular events. We investigated the predictive value of serum cystatin C for controlling hypertension in an observational study. Methods: We screened 1037 adults residing in both rural and urban communities. They were grouped based on their diagnosis and control of hypertension. Results: Serum cystatin C levels in patients with uncontrolled hypertension were higher than those in patients with controlled hypertension (0.98±0.23 mg/L vs. 0.89±0.19 mg/L, p=0.001). However, serum creatinine levels were similar between these groups (0.72±0.20 mg/dL vs. 0.70±0.18 mg/dL, p=0.89). Serum cystatin C levels increased the probability of uncontrolled hypertension independent from confounding factors (odds ratio, 1.48; 95% confidence interval, 1.09-5.64; p=0.03). Conclusion: Subtle kidney dysfunction may be detected using serum cystatin C concentrations among patients with poor blood pressure control and normal serum creatinine levels. |
| Databáze: | MEDLINE |
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