The interrelatedness of chronic cough and chronic pain.

Autor:	Arinze JT; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.; Dept of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands., Verhamme KMC; Dept of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands.; Dept of Bioanalysis, Ghent University, Ghent, Belgium., Luik AI; Dept of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., Stricker B; Dept of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., van Meurs JBJ; Dept of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Brusselle GG; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.; Dept of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.; Dept of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	The European respiratory journal [Eur Respir J] 2021 May 06; Vol. 57 (5). Date of Electronic Publication: 2021 May 06 (Print Publication: 2021).
DOI:	10.1183/13993003.02651-2020
Abstrakt:	Since chronic cough has common neurobiological mechanisms and pathophysiology with chronic pain, both clinical disorders might be interrelated. Hence, we examined the association between chronic cough and chronic pain in adult subjects in the Rotterdam Study, a large prospective population-based cohort study.Using a standardised questionnaire, chronic pain was defined as pain lasting up to 6 months and grouped into a frequency of weekly/monthly or daily pain. Chronic cough was described as daily coughing for at least 3 months duration. The longitudinal and cross-sectional associations were investigated bi-directionally.Of 7141 subjects in the study, 54% (n=3888) reported chronic pain at baseline. The co-prevalence of daily chronic pain and chronic cough was 4.4%. Chronic cough was more prevalent in subjects with daily and weekly/monthly chronic pain compared with those without chronic pain (13.8% and 10.3% versus 8.2%; p<0.001). After adjustment for potential confounders, prevalent chronic pain was significantly associated with incident chronic cough (OR 1.47, 95% CI 1.08-1.99). The association remained significant in subjects with daily chronic pain (OR 1.49, 95% CI 1.06-2.11) with a similar effect estimate, albeit non-significant in those with weekly/monthly chronic pain (OR 1.43, 95% CI 0.98-2.10). After adjustment for covariables, subjects with chronic cough had a significant risk of developing chronic pain (OR 1.63, 95% CI 1.02-2.62) compared with those without chronic cough.Chronic cough and chronic pain confer risk on each other among adult subjects, indicating that both conditions might share common risk factors and/or pathophysiologic mechanisms. Competing Interests: Conflict of interest: J.T. Arinze reports grants from MSD (doctoral research grant), outside the submitted work. Conflict of interest: K.M.C. Verhamme works for a research group who in the past received unconditional grants from Yamanouchi, Pfizer/Boehringer Ingelheim, Novartis and GSK, none of which relate to the content of this work. Conflict of interest: A.I. Luik has nothing to disclose. Conflict of interest: B. Stricker has nothing to disclose. Conflict of interest: J.B.J. van Meurs has nothing to disclose. Conflict of interest: G.G. Brusselle reports personal fees from Astra Zeneca (advisory boards and speaker's fees), Boehringer-Ingelheim (advisory boards and speaker's fees), Chiesi (advisory boards and speaker's fees), GlaxoSmithKline (advisory boards and speaker's fees), Novartis (advisory boards and speaker's fees), Sanofi (advisory boards) and Teva (advisory boards and speaker's fees), and grants from MSD, outside the submitted work. (Copyright ©ERS 2021.)
Databáze:	MEDLINE
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