Brain MR Spectroscopic Findings in 3 Consecutive Patients with COVID-19: Preliminary Observations.

Autor:	Rapalino O; From the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.) orapalino@mgh.harvard.edu., Weerasekera A; From the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.).; A.A. Martinos Center for Biomedical Imaging (A.W., A.T.-C., M.L.L., E.R.), Charlestown, Massachusetts., Moum SJ; Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine (S.J.M.)., Eikermann-Haerter K; From the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.)., Edlow BL; Neurology (B.L.E., D.F., S.S.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Fischer D; Neurology (B.L.E., D.F., S.S.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Torrado-Carvajal A; A.A. Martinos Center for Biomedical Imaging (A.W., A.T.-C., M.L.L., E.R.), Charlestown, Massachusetts.; Medical Image Analysis and Biometry Laboratory (A.T.-C.), Universidad Rey Juan Carlos, Madrid, Spain., Loggia ML; From the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.).; A.A. Martinos Center for Biomedical Imaging (A.W., A.T.-C., M.L.L., E.R.), Charlestown, Massachusetts., Mukerji SS; Neurology (B.L.E., D.F., S.S.M.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Schaefer PW; From the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.)., Gonzalez RG; From the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.)., Lev MH; From the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.)., Ratai EM; From the Departments of Radiology (O.R., A.W., K.E.-H., M.L.L., P.W.S., R.G.G., M.H.L., E.R.).; A.A. Martinos Center for Biomedical Imaging (A.W., A.T.-C., M.L.L., E.R.), Charlestown, Massachusetts.
Jazyk:	angličtina
Zdroj:	AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2021 Jan; Vol. 42 (1), pp. 37-41. Date of Electronic Publication: 2020 Oct 29.
DOI:	10.3174/ajnr.A6877
Abstrakt:	Brain multivoxel MR spectroscopic imaging was performed in 3 consecutive patients with coronavirus disease 2019 (COVID-19). These included 1 patient with COVID-19-associated necrotizing leukoencephalopathy, another patient who had a recent pulseless electrical activity cardiac arrest with subtle white matter changes, and a patient without frank encephalopathy or a recent severe hypoxic episode. The MR spectroscopic imaging findings were compared with those of 2 patients with white matter pathology not related to Severe Acute Respiratory Syndrome coronavirus 2 infection and a healthy control subject. The NAA reduction, choline elevation, and glutamate/glutamine elevation found in the patient with COVID-19-associated necrotizing leukoencephalopathy and, to a lesser degree, the patient with COVID-19 postcardiac arrest, follow a similar pattern as seen with the patient with delayed posthypoxic leukoencephalopathy. Lactate elevation was most pronounced in the patient with COVID-19 necrotizing leukoencephalopathy. (© 2021 by American Journal of Neuroradiology.)
Databáze:	MEDLINE
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