Intracellular Transport of Ribosome-Inactivating Proteins Depends on Annexin 13.

Autor: Maltseva DV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. dmaltseva@gmail.com.; Scientific Research Center Bioclinicum, Moscow, Russia. dmaltseva@gmail.com.; Faculty of Biology and Biotechnology, National Research University Higher School of Economics, Moscow, Russia. dmaltseva@gmail.com., Raigorodskaya MP; Scientific Research Center Bioclinicum, Moscow, Russia., Zgoda VG; Institute of Biomedical Chemistry, Moscow, Russia., Tonevitsky EA; Development Fund of the Mendeleev Valley Innovation Science and Technology Center, Moscow, Russia., Knyazev EN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. knyazevevg@gmail.com.
Jazyk: angličtina
Zdroj: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2020 Sep; Vol. 494 (1), pp. 219-221. Date of Electronic Publication: 2020 Oct 20.
DOI: 10.1134/S1607672920040092
Abstrakt: In the present study, we assessed the role of annexin 13 membrane-binding protein (ANXA13) in the intracellular transport of vesicles containing type II ribosome-inactivating proteins (RIP-IIs). A modified human intestinal epithelial cell line HT29 was used, in which the expression of ANXA13 was significantly reduced. The cytotoxic effect of ricin and viscumin was evaluated by modification of 28S ribosome RNA. The observed differences in the activity of toxins on the parental and modified HT29 lines indicate that ANXA13 plays a different role in the intracellular transport of vesicles containing the RIP-IIs.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje