Lung cancer risk in painters: results from the SYNERGY pooled case-control study consortium.

Autor:	Guha N; International Agency for Research on Cancer, Lyon, France.; California Environmental Protection Agency, Oakland, California, USA., Bouaoun L; International Agency for Research on Cancer, Lyon, France., Kromhout H; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., Vermeulen R; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., Brüning T; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University (IPA), Bochum, Germany., Behrens T; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University (IPA), Bochum, Germany., Peters S; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands., Luzon V; International Agency for Research on Cancer, Lyon, France., Siemiatycki J; Department of Social and Preventive Medicine, University of Montreal, Montreal, Quebec, Canada., Xu M; Department of Social and Preventive Medicine, University of Montreal, Montreal, Quebec, Canada., Kendzia B; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University (IPA), Bochum, Germany., Guenel P; Center for Research in Epidemiology and Population Health (CESP), Exposome and Heredity team, Inserm U1018, University Paris-Saclay, Villejuif, France., Luce D; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Pointe-à-Pitre, France., Karrasch S; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital of Munich, Ludwig-Maximilians-Universität; Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munchen, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Wichmann HE; Institut für Medizinische Informatik Biometrie Epidemiologie, Ludwig Maximilians University, Munich, Germany.; Institut für Epidemiologie, Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany., Consonni D; Epidemiology Unit, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy., Landi MT; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Caporaso NE; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Gustavsson P; Institute of Environmental Medicine, Unit of Occupational Medicine, Karolinska Institute, Stockholm, Sweden., Plato N; Institute of Environmental Medicine, Unit of Occupational Medicine, Karolinska Institute, Stockholm, Sweden., Merletti F; Department of Medical Sciences, Cancer Epidemiology Unit, University of Turin, Turin, Italy., Mirabelli D; Department of Medical Sciences, Cancer Epidemiology Unit, University of Turin, Turin, Italy., Richiardi L; Department of Medical Sciences, Cancer Epidemiology Unit, University of Turin, Turin, Italy., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany., Ahrens W; Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.; Faculty of Mathematics and Computer Science, Institute of Statistics, University of Bremen, Bremen, Germany., Pohlabeln H; Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany., Tse LA; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, Hong Kong., Yu IT; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, Hong Kong., Tardón A; Department of Public Health, University of Oviedo, ISPA and CIBERESP, Oviedo, Spain., Boffetta P; Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, USA.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Zaridze D; Department of Cancer Epidemiology and Prevention, N.N. Blokhin National Research Centre of Oncology, Moscow, Russian Federation., 't Mannetje A; Centre for Public Health Research, Massey University, Wellington, New Zealand., Pearce N; Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK., Davies MPA; Department of Molecular and Clinical Cancer Medicine, University of Liverpool. Roy Castle Lung Cancer Foundation, Liverpool, UK., Lissowska J; Epidemiology Unit, Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Świątkowska B; Health Capital School; Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland., McLaughlin J; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Demers PA; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Occupational Cancer Research Centre, Ontario Health, Toronto, Ontario, Canada., Bencko V; Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University, Prague, Czech Republic., Foretova L; Masaryk Memorial Cancer Institute, Brno, Jihomoravský, Czech Republic., Janout V; Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic., Pándics T; National Public Health Center, Budapest, Hungary., Fabianova E; Occupational Health and Toxicology, Regional Authority of Public Health, Banska Bystrica, Slovakia.; Faculty of Health, Catholic University, Ružomberok, Slovakia., Mates D; National Institute of Public Health, Bucharest, Romania., Forastiere F; Department of Epidemiology, ASL Roma E, Rome, Italy., Bueno-de-Mesquita B; Former senior scientist, Department for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Schüz J; International Agency for Research on Cancer, Lyon, France., Straif K; International Agency for Research on Cancer, Lyon, France., Olsson A; International Agency for Research on Cancer, Lyon, France olssona@iarc.fr.
Jazyk:	angličtina
Zdroj:	Occupational and environmental medicine [Occup Environ Med] 2021 Apr; Vol. 78 (4), pp. 269-278. Date of Electronic Publication: 2020 Oct 28.
DOI:	10.1136/oemed-2020-106770
Abstrakt:	Objectives: We evaluated the risk of lung cancer associated with ever working as a painter, duration of employment and type of painter by histological subtype as well as joint effects with smoking, within the SYNERGY project. Methods: Data were pooled from 16 participating case-control studies conducted internationally. Detailed individual occupational and smoking histories were available for 19 369 lung cancer cases (684 ever employed as painters) and 23 674 age-matched and sex-matched controls (532 painters). Multivariable unconditional logistic regression models were adjusted for age, sex, centre, cigarette pack-years, time-since-smoking cessation and lifetime work in other jobs that entailed exposure to lung carcinogens. Results: Ever having worked as a painter was associated with an increased risk of lung cancer in men (OR 1.30; 95% CI 1.13 to 1.50). The association was strongest for construction and repair painters and the risk was elevated for all histological subtypes, although more evident for small cell and squamous cell lung cancer than for adenocarcinoma and large cell carcinoma. There was evidence of interaction on the additive scale between smoking and employment as a painter (relative excess risk due to interaction >0). Conclusions: Our results by type/industry of painter may aid future identification of causative agents or exposure scenarios to develop evidence-based practices for reducing harmful exposures in painters. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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