Semantic Processing in Healthy Aging and Alzheimer's Disease: A Systematic Review of the N400 Differences.

Autor: Joyal M; CERVO Brain Research Center, Institut Universitaire en Santé Mentale de Québec, Centre Intégré Universitaire de Santé et de Services Sociaux de la Capitale-Nationale, 2601 Chemin de la Canardière, Québec, QC G1J 2G3, Canada.; Faculty of Medicine, Université Laval, Pavillon Ferdinand-Vandry, 1050 Avenue de la Médecine, Québec, QC G1V 0A6, Canada., Groleau C; CERVO Brain Research Center, Institut Universitaire en Santé Mentale de Québec, Centre Intégré Universitaire de Santé et de Services Sociaux de la Capitale-Nationale, 2601 Chemin de la Canardière, Québec, QC G1J 2G3, Canada.; Faculty of Medicine, Université Laval, Pavillon Ferdinand-Vandry, 1050 Avenue de la Médecine, Québec, QC G1V 0A6, Canada., Bouchard C; CERVO Brain Research Center, Institut Universitaire en Santé Mentale de Québec, Centre Intégré Universitaire de Santé et de Services Sociaux de la Capitale-Nationale, 2601 Chemin de la Canardière, Québec, QC G1J 2G3, Canada.; Faculty of Medicine, Université Laval, Pavillon Ferdinand-Vandry, 1050 Avenue de la Médecine, Québec, QC G1V 0A6, Canada., Wilson MA; CERVO Brain Research Center, Institut Universitaire en Santé Mentale de Québec, Centre Intégré Universitaire de Santé et de Services Sociaux de la Capitale-Nationale, 2601 Chemin de la Canardière, Québec, QC G1J 2G3, Canada.; Faculty of Medicine, Université Laval, Pavillon Ferdinand-Vandry, 1050 Avenue de la Médecine, Québec, QC G1V 0A6, Canada., Fecteau S; CERVO Brain Research Center, Institut Universitaire en Santé Mentale de Québec, Centre Intégré Universitaire de Santé et de Services Sociaux de la Capitale-Nationale, 2601 Chemin de la Canardière, Québec, QC G1J 2G3, Canada.; Faculty of Medicine, Université Laval, Pavillon Ferdinand-Vandry, 1050 Avenue de la Médecine, Québec, QC G1V 0A6, Canada.
Jazyk: angličtina
Zdroj: Brain sciences [Brain Sci] 2020 Oct 23; Vol. 10 (11). Date of Electronic Publication: 2020 Oct 23.
DOI: 10.3390/brainsci10110770
Abstrakt: Semantic deficits are common in individuals with Alzheimer's disease (AD). These deficits notably impact the ability to understand words. In healthy aging, semantic knowledge increases but semantic processing (i.e., the ability to use this knowledge) may be impaired. This systematic review aimed to investigate semantic processing in healthy aging and AD through behavioral responses and the N400 brain event-related potential. The results of the quantitative and qualitative analyses suggested an overall decrease in accuracy and increase in response times in healthy elderly as compared to young adults, as well as in individuals with AD as compared to age-matched controls. The influence of semantic association, as measured by N400 effect amplitudes, appears smaller in healthy aging and even more so in AD patients. Thus, semantic processing differences may occur in both healthy and pathological aging. The establishment of norms of healthy aging for these outcomes that vary between normal and pathological aging could eventually help early detection of AD.
Databáze: MEDLINE
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