A comparison of health care worker-collected foam and polyester nasal swabs in convalescent COVID-19 patients.

Autor: Hart B; Research and Development, UnitedHealth Group, Minnetonka, MN, United States of America., Tu YP; The Everett Clinic, Everett, WA, United States of America., Jennings R; Applied Research Associates, Albuquerque, NM, United States of America., Verma P; Research and Development, UnitedHealth Group, Minnetonka, MN, United States of America., Padgett LR; Quantigen Biosciences, Fishers, IN, United States of America., Rains D; Quantigen Biosciences, Fishers, IN, United States of America., Vojta D; Research and Development, UnitedHealth Group, Minnetonka, MN, United States of America., Berke EM; Research and Development, UnitedHealth Group, Minnetonka, MN, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Oct 27; Vol. 15 (10), pp. e0241100. Date of Electronic Publication: 2020 Oct 27 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0241100
Abstrakt: Both polyester and foam nasal swabs were collected from convalescent COVID-19 patients at a single visit and stored in viral transport media (VTM), saline or dry. Sensitivity of each swab material and media combination were estimated, three by three tables were constructed to measure polyester and foam concordance, and cycle threshold (Ct) values were compared. 126 visits had polyester and foam swabs stored in viral transport media (VTM), 51 had swabs stored in saline, and 63 had a foam swab in VTM and a polyester swab stored in a dry tube. Polyester and foam swabs had an estimated sensitivity of 87.3% and 94.5% respectively in VTM, 87.5% and 93.8% respectively in saline, and 75.0% and 90.6% respectively for dry polyester and foam VTM. Polyester and foam Ct values were correlated, but polyester showed decreased performance for cases with a viral load near the detection threshold and higher Ct values on average.
Competing Interests: Brian Hart, Rachel Jennings, Prateek Verma, Deneen Vojta, and Ethan Berke were employees of UnitedHealth Group during the design and analysis of the study and initial drafting of the manuscript. Yuan-Po Tu is an employee of The Everett Clinic, which is a subsidiary of UnitedHealth Group. Leah R. Padgett and Douglas Rains are employees of Quantigen Biosciences and have performed contract services for Thermo Fisher Scientific. The specific roles of these authors are articulated in the ‘author contributions’ section. The competing interests implied by the authors’ employer/employee relationships do not alter our adherence to PLOS ONE policies on sharing data and materials.
Databáze: MEDLINE
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