| Autor: |
Sokoudjou JB; Research Unit of Microbiology and Antimicrobial Substances, Faculty of Science, University of Dschang, Dschang, Cameroon.; Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan., Tagousop CN; Department of Basic Scientific Studies, University Institute of Technology, University of Ngaoundere, Ngaoundere, Cameroon.; Research Unit of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Khan A; Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan., Fodouop SPC; Department of Biomedical Sciences, University of Ngaoundere, Ngaoundere, Cameroon., Atsafack SS; Research Unit of Microbiology and Antimicrobial Substances, Faculty of Science, University of Dschang, Dschang, Cameroon., Kodjio N; Research Unit of Microbiology and Antimicrobial Substances, Faculty of Science, University of Dschang, Dschang, Cameroon., Atolani O; Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan.; Department of Chemistry, Faculty of Physical Sciences, University of Ilorin, Ilorin, Nigeria., Gatsing D; Research Unit of Microbiology and Antimicrobial Substances, Faculty of Science, University of Dschang, Dschang, Cameroon. |
| Abstrakt: |
One new tirucallane triterpene named as canarimoic acid ( 1 ), and three known analogues: 3 β -hydroxytirucalla-8,24-dien-21-oic acid ( 2 ), 3 α -acetyltirucalla-8,24-diene-21oic acid ( 3 ) and 3-oxotirucalla-8,24-dien-21-oic ( 4 ) were isolated from the hydro-ethanolic crude extract of Canarium schweinfurthii . Their structures were established by extensive analysis of 1 D and 2 D NMR data in conjunction with mass spectrometry and by comparison with those reported in the literature. The evaluation of their antisalmonellal activity using broth microdilution method showed that compound 3 was the most active (MIC =16 µg/mL) against Salmonella Typhi and Salmonella Typhimurium followed by compound 1 (MIC= 32 µg/mL) against Salmonella Typhi and Salmonella Enteritidis . |
