Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2: a New Challenge amid the Pandemic.

Autor: Lawrensia S; School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jl. Pluit Raya No. 2, RT 21/RW 08, Penjaringan, Kota Jakarta Utara, Daerah Khusus Ibukota Jakarta, 14440 Indonesia., Henrina J; School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jl. Pluit Raya No. 2, RT 21/RW 08, Penjaringan, Kota Jakarta Utara, Daerah Khusus Ibukota Jakarta, 14440 Indonesia.; Siloam Heart Institute, Siloam Hospital Kebon Jeruk, Jl. Perjuangan No.8, RT.14/RW.10, Kb. Jeruk, Kec. Kb. Jeruk, Kota Jakarta Barat, Daerah Khusus Ibukota Jakarta, 11530 Indonesia., Wijaya E; Department of Pediatrics, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jl. Pluit Raya No. 2, RT 21/RW 08, Penjaringan, Kota Jakarta Utara, Daerah Khusus Ibu kota Jakarta, 14440 Indonesia., Suciadi LP; Siloam Heart Institute, Siloam Hospital Kebon Jeruk, Jl. Perjuangan No.8, RT.14/RW.10, Kb. Jeruk, Kec. Kb. Jeruk, Kota Jakarta Barat, Daerah Khusus Ibukota Jakarta, 11530 Indonesia., Saboe A; Cardiology and Vascular Department, Padjadjaran University, Jl. Professor Eyckman No. 38, Pasteur, Kec. Sukajadi, Kota Bandung, Jawa Barat 40161 Indonesia., Cool CJ; Cardiology and Vascular Department, Padjadjaran University, Jl. Professor Eyckman No. 38, Pasteur, Kec. Sukajadi, Kota Bandung, Jawa Barat 40161 Indonesia.
Jazyk: angličtina
Zdroj: SN comprehensive clinical medicine [SN Compr Clin Med] 2020; Vol. 2 (11), pp. 2077-2085. Date of Electronic Publication: 2020 Oct 22.
DOI: 10.1007/s42399-020-00602-8
Abstrakt: Initially, SARS-CoV-2 infection had been reported as a relatively mild case in children than in adults. Nevertheless, recent evidence found that a subset of children then developed a significant systemic inflammatory response that resembles atypical/typical Kawasaki's disease (KD) and toxic shock syndrome. This novel clinical syndrome later identified as pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS). In contrast with KD, PIMS-TS appears to occur in children at an older age with a predominance of gastrointestinal symptoms, hemodynamic instability, and myocardial dysfunction. However, the exact pathomechanism remains to be understood. Nevertheless, the post-viral immunological reaction is postulated to be the underlying mechanistic underpinnings. The multifaceted nature of the PIMS-TS' course underlines the need for early recognition and multispecialty care and management.
Competing Interests: Conflict of InterestThe authors declare that they have no competing interests.
(© Springer Nature Switzerland AG 2020.)
Databáze: MEDLINE
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