| Autor: |
Sas AR; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.; The Neuroscience Research Institute, The Ohio State University, Columbus, OH, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI, USA., Carbajal KS; Department of Neurology, University of Michigan, Ann Arbor, MI, USA., Jerome AD; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.; The Neuroscience Research Institute, The Ohio State University, Columbus, OH, USA., Menon R; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Yoon C; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA., Kalinski AL; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA., Giger RJ; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA., Segal BM; Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. benjamin.segal@osumc.edu.; The Neuroscience Research Institute, The Ohio State University, Columbus, OH, USA. benjamin.segal@osumc.edu.; Department of Neurology, University of Michigan, Ann Arbor, MI, USA. benjamin.segal@osumc.edu. |
| Abstrakt: |
Transected axons typically fail to regenerate in the central nervous system (CNS), resulting in chronic neurological disability in individuals with traumatic brain or spinal cord injury, glaucoma and ischemia-reperfusion injury of the eye. Although neuroinflammation is often depicted as detrimental, there is growing evidence that alternatively activated, reparative leukocyte subsets and their products can be deployed to improve neurological outcomes. In the current study, we identify a unique granulocyte subset, with characteristics of an immature neutrophil, that had neuroprotective properties and drove CNS axon regeneration in vivo, in part via secretion of a cocktail of growth factors. This pro-regenerative neutrophil promoted repair in the optic nerve and spinal cord, demonstrating its relevance across CNS compartments and neuronal populations. Our findings could ultimately lead to the development of new immunotherapies that reverse CNS damage and restore lost neurological function across a spectrum of diseases. |
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