Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice.

Autor:	Khan A; Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia., Muhamad NA; Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia., Ismail H; Department of Biochemistry and Biotechnology, University of Gujrat, Gujrat 50700, Pakistan., Nasir A; Department of Molecular Science and Technology, Ajou University, Suwan 16499, Korea., Khalil AAK; Department of Biological Sciences, National University of Medical Sciences, Rawalpindi 46000, Pakistan., Anwar Y; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah P.O. Box 54229, Saudi Arabia., Khan Z; Department of Pharmacognosy, Faculty of Pharmacy, Federal Urdu University of Arts Science and Technology, Karachi 75300, Pakistan., Ali A; Department of Botany, University of Malakand, Khyber Pakhtunkhwa 18800, Pakistan., Taha RM; Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia., Al-Shara B; Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia., Latif S; Department of Biochemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan., Mirza B; Department of Biochemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.; Lahore College for Women University, Lahore 54000, Pakistan., Fadladdin YAJ; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah P.O. Box 54229, Saudi Arabia., Zeid IMA; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah P.O. Box 54229, Saudi Arabia., Al-Thobaiti SA; Department of Biology, University College Turabah, Taif University, Taif 21995, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Plants (Basel, Switzerland) [Plants (Basel)] 2020 Oct 22; Vol. 9 (11). Date of Electronic Publication: 2020 Oct 22.
DOI:	10.3390/plants9111414
Abstrakt:	Crocus sativus, a medicinally important herbaceous plant, has been traditionally used to cure coughs, colds, insomnia, cramps, asthma, and pain. Moreover, the therapeutic applications of saffron include its immunomodulatory and anticancer properties. The current experimental analysis was performed to explore the potential nutraceutical efficacy of corm, leaf, petal, and stigma of saffron ethanolic extracts as analgesic, anti-inflammatory, anticoagulant, and antidepressant using hot plate, carrageenan-induced paw edema, capillary tube and forced swim test, respectively in mice. The results indicated that among all the extracts, stigma ethanolic extract (SEE) represented maximum latency activity (72.85%) and edema inhibition (77.33%) followed by petal ethanolic extract (PEE) with latency activity and edema inhibition of 64.06 and 70.50%, respectively. Corm ethanolic extract (CEE) and leaf ethanolic extract (LEE) displayed mild analgesic activity of 22.40% and 29.07%, respectively. Additionally, LEE (53.29%) and CEE (47.47%) exhibited mild to moderate response against inflammation. The coagulation time of SEE (101.66 s) was almost equivalent to the standard drug, aspirin (101.66 s), suggesting a strong anticoagulant effect followed by PEE (86.5 s). LEE (66.83 s) represented moderate inhibitory effect on coagulation activity while CEE (42.83 s) showed neutral effect. Additionally, PEE and SEE also expressed itself as potential antidepressants with immobility time ≤76.66 s, while CEE (96.50 s) and LEE (106.83 s) indicated moderate to mild antidepressant efficacy. Based on the in vivo activities, saffron extract, particularly SEE and PEE, can be used as a potential nutraceutical and therapeutic agent due to its significant pharmacological activities. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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