Ion Mobility Spectrometry with High Ion Utilization Efficiency Using Traveling Wave-Based Structures for Lossless Ion Manipulations.

Autor: Li A; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States., Nagy G; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States., Conant CR; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States., Norheim RV; Environmental and Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, United States., Lee JY; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States., Giberson C; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States., Hollerbach AL; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States., Prabhakaran V; Physical Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States., Attah IK; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States., Chouinard CD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States., Prabhakaran A; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States., Smith RD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States., Ibrahim YM; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States., Garimella SVB; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.
Jazyk: angličtina
Zdroj: Analytical chemistry [Anal Chem] 2020 Nov 17; Vol. 92 (22), pp. 14930-14938. Date of Electronic Publication: 2020 Oct 26.
DOI: 10.1021/acs.analchem.0c02100
Abstrakt: Ion packets introduced from gates, ion funnel traps, and other conventional ion injection mechanisms produce ion pulse widths typically around a few microseconds or less for ion mobility spectrometry (IMS)-based separations on the order of 100 milliseconds. When such ion injection techniques are coupled with ultralong path length traveling wave (TW)-based IMS separations (i.e., on the order of seconds) using structures for lossless ion manipulations (SLIMs), typically very low ion utilization efficiency is achieved for continuous ion sources [e.g., electrospray ionization (ESI)]. Even with the ability to trap and accumulate much larger populations of ions than being conventionally feasible over longer time periods in SLIM devices, the subsequent long separations lead to overall low ion utilization. Here, we report the use of a highly flexible SLIM arrangement, enabling concurrent ion accumulation and separation and achieving near-complete ion utilization with ESI. We characterize the ion accumulation process in SLIM, demonstrate >98% ion utilization, and show both increased signal intensities and measurement throughput. This approach is envisioned to have broad utility to applications, for example, involving the fast detection of trace chemical species.
Databáze: MEDLINE