Investigating Pneumonia Etiology Among Refugees and the Lebanese population (PEARL): A study protocol.

Autor:	Kesteman T; Fondation Mérieux, Lyon, 69002, France., Ghassani A; Amel Association, Beirut, Lebanon., Hajjar C; Faculté de Pharmacie, Université Saint-Joseph, Beirut, Lebanon., Picot V; Fondation Mérieux, Lyon, 69002, France., Osman M; Laboratoire Microbiologie Santé et Environnement, Lebanese University, Tripoli, Lebanon., Alnajjar Z; Chtoura Hospital, Chtoura, Lebanon., Komurian-Pradel F; Fondation Mérieux, Lyon, 69002, France., Messaoudi M; Fondation Mérieux, Lyon, 69002, France., Pouzol S; Fondation Mérieux, Lyon, 69002, France., Soulaiman HG; Al-Bashaer Medical Center, Tripoli, Lebanon., Vanhems P; Infection Control and Epidemiology Unit, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, 69002, France., Ramilo O; Nationwide Childrens' Hospital and the Ohio State University College of Medicine, Columbus, OH, 43205, USA., Karam-Sarkis D; Laboratoire des Agents Pathogènes, Faculté de Pharmacie, Université Saint-Joseph, Beirut, Lebanon.; Laboratoire Rodolphe Mérieux, Université Saint-Joseph, Beirut, Lebanon., Najjar-Pellet J; Fondation Mérieux, Lyon, 69002, France., Hamze M; Laboratoire Microbiologie Santé et Environnement, Lebanese University, Tripoli, Lebanon., Endtz H; Fondation Mérieux, Lyon, 69002, France.; Erasmus Medical Center, Rotterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	Gates open research [Gates Open Res] 2019 Jun 13; Vol. 2, pp. 19. Date of Electronic Publication: 2019 Jun 13 (Print Publication: 2018).
DOI:	10.12688/gatesopenres.12811.2
Abstrakt:	Background: Community-acquired pneumonia (CAP), a leading cause of mortality, mainly affects children in developing countries. The harsh circumstances experienced by refugees include various factors associated with respiratory pathogen transmission, and clinical progression of CAP. Consequently, the etiology of CAP in humanitarian crisis situations may differ to that of settled populations, which would impact appropriate case management. Therefore, the Pneumonia Etiology Among Refugees and the Lebanese population (PEARL) study was initiated with the objective of identifying the causal pathogenic microorganisms in the respiratory tract of children and adults from both the refugee and host country population presenting with signs of CAP during a humanitarian crisis. Methods: PEARL, a prospective, multicentric, case-control study, will be conducted at four primary healthcare facilities in Tripoli and the Bekaa valley over 15 months (including two high-transmission seasons/winters). Sociodemographic and medical data, and biological samples will be collected from at least 600 CAP cases and 600 controls. Nasopharyngeal swabs, sputum, urine and blood samples will be analyzed at five clinical pathology laboratories in Lebanon to identify the bacterial and viral etiological agents of CAP. Transcriptomic profiling of host leukocytes will be performed. Conclusions: PEARL is an original observational study that will provide important new information on the etiology of pneumonia among refugees, which may improve case management, help design antimicrobial stewardship interventions, and reduce morbidity and mortality due to CAP in a humanitarian crisis. Competing Interests: No competing interests were disclosed. (Copyright: © 2019 Kesteman T et al.)
Databáze:	MEDLINE
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