| Autor: |
Kasozi KI; School of Medicine, Kabale University, Box 317 Kabale, Uganda.; Infection Medicine, Deanery of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, United Kingdom., Nakimbugwe D; Department of Food Technology & Nutrition, School of Food Technology, Nutrition & Bio-Engineering, Makerere University, Kampala, Uganda., Ninsiima HI; School of Medicine, Kabale University, Box 317 Kabale, Uganda., Kasolo J; Department of Physiology, College of Health Sciences, Makerere University, Kampala, Uganda., Matama K; Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy, Kampala International University Western Campus, Box 71, Bushenyi, Uganda., Safiriyu AA; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, India.; Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71 Bushenyi, Uganda., Owembabazi E; School of Anatomical Science, University of the Witwatersrand, 29 Princess of Wales Terrace, Johannesburg, South Africa.; Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71 Bushenyi, Uganda., Ssempijja F; Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71 Bushenyi, Uganda., Okpanachi AO; Department of Physiology, Faculty of Biomedical Sciences, Kampala International University Western Campus, Box 71 Bushenyi, Uganda., Valladares MB; Department of Physiology, Medical University of Camagüey, Camaguey, Cuba. |
| Abstrakt: |
Objectives Calcium deregulation in diabetes mellitus (DM) is central to the brain-heart axis pathology. This has led to the use of medical plants in complementary medicine such as Amaranthus hypochondriacus (GA). The objective of the study was to establish the effects of grain amaranth feed supplementation on calcium, s100al protein and antioxidant levels on the brain-heart axis in diabetic male Wistar rats. Methods The study involved six groups (n=5) with DM being induced in 20 rats. To the diabetic rats, Group I received mixtard®, Group II was positive control, Groups III and IV received GA feed supplementation at 25 and 50%. In the nondiabetic rats (n=10), Group V received 50% grain amaranth while Group VI was the negative control. The brain and heart tissues were harvested after five weeks and processed using standard methods. Results Grain amaranth feed supplementation led to improved calcium levels in DM as compared to the positive control. This also led to increased s100a1, antioxidant levels in the brain-heart axis during DM. This then protected the tissues against oxidative damage, thus preserving tissue function and structure. Conclusions Grain amaranth's actions on calcium signaling subsequently affected s100a1 protein levels, leading to improved tissue function in diabetes. |
