Dopamine D4 receptor modulates inhibitory transmission in pallido-pallidal terminals and regulates motor behavior.

Autor: Conde Rojas I; Departamento de Fisiología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México, México., Acosta-García J; Universidad Tecnológica de México, UNITEC MÉXICO, México, México., Caballero-Florán RN; Department of Pharmachology, Medical School University of Michigan, Ann Arbor, MI, USA., Jijón-Lorenzo R; Departamento de Fisiología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México, México., Recillas-Morales S; Faculty of Veterinary Medicine, Universidad Autónoma del Estado de México, Toluca, Estado de México, México., Avalos-Fuentes JA; Departamento de Fisiología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México, México., Paz-Bermúdez F; Departamento de Fisiología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México, México., Leyva-Gómez G; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, México., Cortés H; Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, México., Florán B; Departamento de Fisiología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México, México.
Jazyk: angličtina
Zdroj: The European journal of neuroscience [Eur J Neurosci] 2020 Dec; Vol. 52 (11), pp. 4563-4585. Date of Electronic Publication: 2020 Nov 08.
DOI: 10.1111/ejn.15020
Abstrakt: Two major groups of terminals release GABA within the Globus pallidus; one group is constituted by projections from striatal neurons, while endings of the intranuclear collaterals form the other one. Each neurons' population expresses different subtypes of dopamine D2-like receptors: D 2 R subtype is expressed by encephalin-positive MSNs, while pallidal neurons express the D 4 R subtype. The D 2 R modulates the firing rate of striatal neurons and GABA release at their projection areas, while the D 4 R regulates Globus pallidus neurons excitability and GABA release at their projection areas. However, it is unknown if these receptors control GABA release at pallido-pallidal collaterals and regulate motor behavior. Here, we present neurochemical evidence of protein content and binding of D 4 R in pallidal synaptosomes, control of [ 3 H] GABA release in pallidal slices of rat, electrophysiological evidence of the presence of D 4 R on pallidal recurrent collaterals in mouse slices, and turning behavior induced by D 4 R antagonist microinjected in amphetamine challenged rats. As in projection areas of pallidal neurons, GABAergic transmission in pallido-pallidal recurrent synapses is under modulation of D 4 R, while the D 2 R subtype, as known, modulates striato-pallidal projections. Also, as in projection areas, D 4 R contributes to control the motor activity differently than D 2 R. This study could help to understand the organization of intra-pallidal circuitry.
(© 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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