Experimental Modeling of Leprosy in BALB/c, BALB/c Nude, CBA, and C57BL/6ТNF -/- Mice.

Autor: Karamova AE; State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia., Semenova VG; State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia., Verbenko DA; State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia., Obraztsova OA; State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia., Vanchugova KM; State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia., Nikonorov AA; State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia. nikonorov_all@mail.ru., Deryabin DG; State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia., Solomka VS; State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia., Kubanov AA; State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2020 Oct; Vol. 169 (6), pp. 836-839. Date of Electronic Publication: 2020 Oct 24.
DOI: 10.1007/s10517-020-04991-7
Abstrakt: Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF -/- mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantitative dependence on the used mouse line. CBA and BALB/cNude mice were optimal for strain R and BALB/c and BALB/cNude lines were optimal for strain I. BALB/cNude mice infected with strain I had low lifespan. M. leprae strain M showed low proliferation activity in BALB/cNude and C57BL/6ТNF -/- mice.
Databáze: MEDLINE
Externí odkaz: