Prevalence of different states of glucose intolerance in Sri Lankan children and adolescents with obesity and its relation to other comorbidities.

Autor:	Ciba I; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.; Uppsala University Children's Hospital, Uppsala, Sweden., Warnakulasuriya LS; Postgraduate Institute of Medicine, University of Colombo, Colombo, Sri Lanka., Adikaram AVN; Health Unit, Bandaranaike International Airport, Katunayake, Sri Lanka., Bergsten P; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.; Uppsala University Children's Hospital, Uppsala, Sweden.; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden., Dahlbom M; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.; Uppsala University Children's Hospital, Uppsala, Sweden., Fernando MMA; Colombo North Teaching Hospital, Ragama, Sri Lanka., Rytter E; Clinical Nutrition and Metabolism, Department of Public Health and Caring Science, Faculty of Medicine, Uppsala University, Uppsala, Sweden., Samaranayake DL; Department of Community Medicine, University of Colombo, Colombo, Sri Lanka., Silva KDRR; Department of Applied Nutrition, Wayamba University of Sri Lanka, Makandura, Sri Lanka., Wickramasinghe VP; Department of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka., Forslund AH; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.; Uppsala University Children's Hospital, Uppsala, Sweden.
Jazyk:	angličtina
Zdroj:	Pediatric diabetes [Pediatr Diabetes] 2021 Mar; Vol. 22 (2), pp. 168-181. Date of Electronic Publication: 2020 Nov 04.
DOI:	10.1111/pedi.13145
Abstrakt:	Background: South Asian adults have higher prevalence of obesity comorbidities than other ethnic groups. Whether this also is true for Sri Lankan children with obesity has rarely been investigated. Objective: To investigate prevalence of glucose intolerance and other comorbidities in Sri Lankan children with obesity and compare them with Swedish children. To identify risk factors associated with glucose intolerance. Subjects: A total of 357 Sri Lankan children (185 boys), aged 7 to 17 years with BMI-SDS ≥2.0 from a cross-sectional school screening in Negombo. A total of 167 subjects from this study population were matched for sex, BMI-SDS and age with 167 Swedish subjects from the ULSCO cohort for comparison. Methods: After a 12 hour overnight fast, blood samples were collected and oral glucose tolerance test was performed. Body fat mass was assessed by bioelectrical impedance assay. Data regarding medical history and socioeconomic status were obtained from questionnaires. Results: Based on levels of fasting glucose (FG) and 2 hours-glucose (2 hours-G), Sri Lankan subjects were divided into five groups: normal glucose tolerance (77.5%, n = 276), isolated impaired fasting glucose according to ADA criteria (9.0%, n = 32), isolated impaired glucose tolerance (8.4%, n = 30), combined impaired fasting glucose (IFG) + impaired glucose tolerance (IGT) (3.1%, n = 11) and type 2 diabetes mellitus (2.0%, n = 7). FG, 2 hours-insulin and educational status of the father independently increased the Odds ratio to have elevated 2 hours-G. Sri Lankan subjects had higher percentage of body fat, but less abdominal fat than Swedish subjects. Conclusion: High prevalence in Sri Lankan children with obesity shows that screening for glucose intolerance is important even if asymptomatic. (© 2020 The Authors. Pediatric Diabetes published by John Wiley & Sons Ltd.)
Databáze:	MEDLINE
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