Value of C-reactive Protein/Albumin Ratio for Predicting Ischemia in Myocardial Perfusion Scintigraphy

Autor: Efe SÇ; Kartal Koşuyolu Cardiovascular Diseases Training and Research Hospital, Clinic of Cardiology, İstanbul, Turkey, Özdemir Candan Ö; İstanbul Training and Research Hospital, Clinic of Internal Medicine, İstanbul, Turkey, Gündoğan C; İstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey, Öz A; İstanbul Training and Research Hospital, Clinic of Cardiology, İstanbul, Turkey, Yüksel Y; İstanbul Training and Research Hospital, Clinic of Cardiology, İstanbul, Turkey, Ayca B; İstanbul Training and Research Hospital, Clinic of Cardiology, İstanbul, Turkey, Çermik TF; İstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey
Jazyk: angličtina
Zdroj: Molecular imaging and radionuclide therapy [Mol Imaging Radionucl Ther] 2020 Oct 19; Vol. 29 (3), pp. 112-117.
DOI: 10.4274/mirt.galenos.2020.88261
Abstrakt: Objectives: Several studies demonstrate the relationship between coronary artery disease and inflammatory parameters. Nevertheless, there is paucity of data regarding the role of high sensitivity (hs)-C-reactive protein (CRP) to albumin ratio (CAR) in patients with ischemia on gated single photon emission tomography (SPECT) myocardial perfusion imaging (MPI). This study was aimed at demonstrating the relationship between CAR and the occurrence of ischemia on gated SPECT MPI.
Methods: We retrospectively evaluated 2.048 referred patients for gated SPECT MPI from a cardiology outpatient clinic between October 2017 and June 2019. After applying exclusion criteria and measuring serum CRP and albumin levels, we included 126 patients in the study. We then classified subjects into different groups according to the absence or presence of ischemia on gated SPECT MPI.
Results: According to laboratory findings, hs-CRP and CAR were significantly higher in the ischemia group, while the serum albumin was significantly lower in ischemia group (p<0.05 for each). The independent predictors of presence of ischemia in multivariate analysis were hypertension and CAR (CAR; odds ratio: 5.720, 95% confidence interval: 2.697-12.133, p<0.001). The optimal value of CAR for presence of ischemia was 0.96 with 76% sensitivity and 71% specificity.
Conclusion: We found CAR values as a predictor for ischemia before MPI.
Databáze: MEDLINE
Externí odkaz: