Cerebrospinal fluid cytotoxicity in amyotrophic lateral sclerosis: a systematic review of in vitro studies.

Autor:	Ng Kee Kwong KC; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Gregory JM; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK.; MRC Edinburgh Brain Bank, Academic Department of Neuropathology, University of Edinburgh, Edinburgh, UK.; Edinburgh Pathology, University of Edinburgh, Edinburgh, UK., Pal S; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK.; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK., Chandran S; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK.; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK.; Centre for Brain Development and Repair, inStem, Bangalore, India., Mehta AR; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for MND Research, University of Edinburgh, Edinburgh, UK.; Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK.; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Jazyk:	angličtina
Zdroj:	Brain communications [Brain Commun] 2020 Aug 06; Vol. 2 (2), pp. fcaa121. Date of Electronic Publication: 2020 Aug 06 (Print Publication: 2020).
DOI:	10.1093/braincomms/fcaa121
Abstrakt:	Various studies have suggested that a neurotoxic cerebrospinal fluid profile could be implicated in amyotrophic lateral sclerosis. Here, we systematically review the evidence for cerebrospinal fluid cytotoxicity in amyotrophic lateral sclerosis and explore its clinical correlates. We searched the following databases with no restrictions on publication date: PubMed, Embase and Web of Science. All studies that investigated cytotoxicity in vitro following exposure to cerebrospinal fluid from amyotrophic lateral sclerosis patients were considered for inclusion. Meta-analysis could not be performed, and findings were instead narratively summarized. Twenty-eight studies were included in our analysis. Both participant characteristics and study conditions including cerebrospinal fluid concentration, exposure time and culture model varied considerably across studies. Of 22 studies assessing cell viability relative to controls, 19 studies reported a significant decrease following exposure to cerebrospinal fluid from patients with amyotrophic lateral sclerosis, while three early studies failed to observe any difference. Seven of eight studies evaluating apoptosis observed significant increases in the levels of apoptotic markers following exposure to cerebrospinal fluid from patients with amyotrophic lateral sclerosis, with the remaining study reporting a qualitative difference. Although five studies investigated the possible relationship between cerebrospinal fluid cytotoxicity and patient characteristics, such as age, gender and disease duration, none demonstrated an association with any of the factors. In conclusion, our analysis suggests that cerebrospinal fluid cytotoxicity is a feature of sporadic and possibly also of familial forms of amyotrophic lateral sclerosis. Further research is, however, required to better characterize its underlying mechanisms and to establish its possible contribution to amyotrophic lateral sclerosis pathophysiology. (© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.)
Databáze:	MEDLINE
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