More continuous flow, better learning? The effect of aortic valve opening in patients with left ventricular assist device.

Autor: Karahan M; Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey., Kocabeyoglu SS; Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey., Kervan U; Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey., Sert DE; Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey., Erdogan Bakar E; Department of Psychology, Ufuk University, Ankara, Turkey., Aygun E; Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey., Tola M; Department of Radiology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey., Demirkan B; Department of Cardiology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey., Mungan S; Department of Neurology, Ankara Numune Hospital, Ankara, Turkey., Catav Z; Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey., Pac M; Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey.
Jazyk: angličtina
Zdroj: The International journal of artificial organs [Int J Artif Organs] 2021 May; Vol. 44 (5), pp. 325-331. Date of Electronic Publication: 2020 Oct 23.
DOI: 10.1177/0391398820963284
Abstrakt: Purpose: The aim of this study was to analyze neurocognitive function in patients who underwent continuous flow left ventricular assist device (LVAD) implantation.
Material and Method: This cross-sectional study included three groups: LVAD ( n  = 31), heart failure patients ( n  = 26), and healthy volunteers ( n  = 27). The Rey Auditory-Verbal Learning Test (RAVLT), Judgement of Line Orientation Test (JLOT), Trail Making Test (TMT), Stroop Color-Word Interference Test (SCWIT), Verbal Fluency Test (VFT), Symbol-Digit Modality Test (SDMT) were used to assess the neurocognitive functions. Data were analyzed at a median 12 (3-47) months after LVAD implantation. The LVAD patients were also divided by aortic valve opening (AVO) into three subgroups as "closed" ( n  = 9), "1-6" ( n  = 8) and "7-10" ( n  = 14) opening per ten beats and data were re-analyzed accordingly.
Results: There was no significant difference among the groups according to SCWIT, JLOT, SDMT, TMT, and VFT scores. Post-hoc analyzes of RAVLT scores showed significant differences between the LVAD and the other two groups in favor of the LVAD group. Also, the patients with AVO "7-10" the response times were longer and learning scores were found to be lower than those without AVO.
Conclusion: With continuous-flow LVAD, neurocognitive functions were not impaired. The learning performance was better in cases where there was no AVO and flow was completely device dependent. We may speculate that neurocognitive functions are not worsening with continuous cerebral blood flow and even it may improve learning performance.
Databáze: MEDLINE
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