The influence of race on cervical length in pregnant women in Brazil.

Autor:	Minis E; Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.; Department of Obstetrics and Gynecology, University Hospital, Newark, NJ, USA., Fernandes Moron A; Department of Obstetrics, Federal University of São Paulo, São Paulo, Brazil., Hatanaka A; Department of Obstetrics, Federal University of São Paulo, São Paulo, Brazil., Sarmento SGP; Department of Obstetrics, Federal University of São Paulo, São Paulo, Brazil., Santucci M; Department of Obstetrics, Federal University of São Paulo, São Paulo, Brazil., Carvalho FHC; Department of Gynecology and Obstetrics, Federal University of Ceara, Fortaleza, Ceara, Brazil., Hamamoto TK; Department of Obstetrics, Federal University of São Paulo, São Paulo, Brazil., Mattar R; Department of Obstetrics, Federal University of São Paulo, São Paulo, Brazil., Linhares IM; Department of Gynecology and Obstetrics, São Paulo University Medical School, São Paulo, Brazil., Sabino EC; Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil., Forney LJ; Department of Biological Sciences and the Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, ID, USA., Witkin SS; Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Jazyk:	angličtina
Zdroj:	Journal of perinatal medicine [J Perinat Med] 2020 Oct 22; Vol. 49 (3), pp. 365-369. Date of Electronic Publication: 2020 Oct 22 (Print Publication: 2021).
DOI:	10.1515/jpm-2020-0065
Abstrakt:	Objectives: Short cervical length is a predictor of preterm birth. We evaluated if there were racial differences in variables associated with cervical length in pregnant Brazilian women. Methods: Cervical length was determined by vaginal ultrasound in 414 women at 21 weeks gestation. All women were seen at the same clinic and analyzed by the same investigators. Women found to have a short cervix (≤25 mm) received vaginal progesterone throughout gestation. Composition of the vaginal microbiome was determined by analysis of the V1-V3 region of the gene coding for bacterial 16S ribosomal RNA. Demographic, clinical and outcome variables were determined by chart review. Subjects were 53.4% White, 37.2% mixed race and 9.4% Black. Results: Pregnancy, medical history and education level were similar in all groups. Mean cervical length was shorter in Black women (28.4 mm) than in White (32.4 mm) or mixed race (32.8 mm) women (p≤0.016) as was the percentage of women with a short cervix (23.1, 12.2, 7.8% in Black, White, mixed race respectively) (p≤0.026). Mean cervical length increased with maternal age in White (p=0.001) and mixed race (p=0.045) women but not Black women. There were no differences in bacterial dominance in the vaginal microbiota between groups. Most women with a short cervix delivered at term. Conclusions: We conclude that Black women in Brazil have a shorter cervical length than White or mixed race women independent of maternal age, pregnancy and demographic history or composition of the vaginal microbiome. (© 2020 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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