Association between brain morphology and electrophysiological features in Congenital Zika Virus Syndrome: A cross-sectional, observational study.

Autor:	Sequerra EB; Brain Institute, Federal University of Rio Grande do Norte, 59056-450 Natal, RN, Brazil., Rocha AJ; Brain Institute, Federal University of Rio Grande do Norte, 59056-450 Natal, RN, Brazil., de Medeiros GOC; Imaging Diagnostic Center, Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, 59012-300 Natal, RN, Brazil., Neto MM; Imaging Diagnostic Center, Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, 59012-300 Natal, RN, Brazil., Maia CRS; Department of Pediatrics, Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, 59012-300 Natal, RN, Brazil., Arrais NMR; Department of Pediatrics, Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, 59012-300 Natal, RN, Brazil., Bezerra M; Department of Pediatrics, Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, 59012-300 Natal, RN, Brazil., Jeronimo SMB; Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte, 59056-450 Natal, RN, Brazil.; National Institute of Science and Technology of Tropical Diseases, Natal, RN, Brazil., Barros AK; Department of Electrical Engineering, Federal University of Maranhão, 65080-040 São Luís, MA, Brazil., Sousa PS; Brain Institute, Federal University of Rio Grande do Norte, 59056-450 Natal, RN, Brazil.; Department of Electrical Engineering, Federal University of Maranhão, 65080-040 São Luís, MA, Brazil., Nogueira de Melo A; Department of Pediatrics, Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, 59012-300 Natal, RN, Brazil., Queiroz CM; Brain Institute, Federal University of Rio Grande do Norte, 59056-450 Natal, RN, Brazil.
Jazyk:	angličtina
Zdroj:	EClinicalMedicine [EClinicalMedicine] 2020 Aug 27; Vol. 26, pp. 100508. Date of Electronic Publication: 2020 Aug 27 (Print Publication: 2020).
DOI:	10.1016/j.eclinm.2020.100508
Abstrakt:	Background: Intrauterine infection with the Zika virus (ZIKV) has been connected to severe brain malformations, microcephaly, and abnormal electrophysiological activity. Methods: We describe the interictal electroencephalographic (EEG) recordings of 47 children born with ZIKV-derived microcephaly. EEGs were recorded in the first year of life and correlated with brain morphology. In 31 subjects, we tested the association between computed tomography (CT) findings and interictal epileptiform discharges (IED). In eighteen, CTs were used for correlating volumetric measurements of the brainstem, cerebellum, and prosencephalon with the rate of IED. Findings: Twenty-nine out of 47 (62%) subjects were diagnosed as having epilepsy. Those subjects presented epileptiform discharges, including unilateral interictal spikes (26/29, 90%), bilateral synchronous and asynchronous interictal spikes (21/29, 72%), and hypsarrhythmia (12/29, 41%). Interestingly, 58% of subjects with clinical epilepsy were born with rhombencephalon malformations, while none of the subjects without epilepsy showed macroscopic abnormalities in this region. The presence of rhombencephalon malformation was associated with epilepsy (odds ratio of 34; 95% CI: 2 - 654). Also, the presence of IED was associated with smaller brain volumes. Age-corrected total brain volume was inversely correlated with the rate of IED during sleep. Finally, 11 of 44 (25%) subjects presented sleep spindles. We observed an odds ratio of 0·25 (95% CI: 0·06 - 1·04) for having sleep spindles given the IED presence. Interpretation: The findings suggest that certain CT imaging features are associated with an increased likelihood of developing epilepsy, including higher rates of IED and impaired development of sleep spindles, in the first year of life of CZVS subjects. Funding: This work was supported by the Brazilian Federal Government through a postdoctoral fellowship for EBS (Talented Youth, Science without Borders), an undergraduate scholarship for AJR (Institutional Program of Science Initiation Scholarships, Federal University of Rio Grande do Norte, Brazil), by International Centre for Genetic Engineering and Biotechnology (CRP/BRA18-05_EC) and by CAPES (Grant number 440893/2016-0), and CNPq (Grant number 88881.130729/2016-01). Competing Interests: We declare no competing interests associated with this work. (© 2020 The Authors.)
Databáze:	MEDLINE
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