Simultaneous BOLD-fMRI and constant infusion FDG-PET data of the resting human brain.

Autor:	Jamadar SD; Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia. sharna.jamadar@monash.edu.; Australian Research Council Centre of Excellence for Integrative Brain Function, Melbourne, Australia. sharna.jamadar@monash.edu.; Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia. sharna.jamadar@monash.edu., Ward PGD; Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia.; Australian Research Council Centre of Excellence for Integrative Brain Function, Melbourne, Australia., Close TG; Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia.; Australian National Imaging Facility, Brisbane, QLD, Australia., Fornito A; Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia.; Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia., Premaratne M; Department of Electrical and Computer Systems Engineering, Monash University, Melbourne, VIC, Australia., O'Brien K; Siemens Healthineers, Siemens Healthcare Pty Ltd, Bayswater, VIC, 3153, Australia., Stäb D; Siemens Healthineers, Siemens Healthcare Pty Ltd, Bayswater, VIC, 3153, Australia., Chen Z; Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia.; Department of Electrical and Computer Systems Engineering, Monash University, Melbourne, VIC, Australia., Shah NJ; Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia.; Institute of Neuroscience and Medicine, Forschungszentrum Jülich, 52425, Jülich, Germany., Egan GF; Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia.; Australian Research Council Centre of Excellence for Integrative Brain Function, Melbourne, Australia.; Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia.
Jazyk:	angličtina
Zdroj:	Scientific data [Sci Data] 2020 Oct 21; Vol. 7 (1), pp. 363. Date of Electronic Publication: 2020 Oct 21.
DOI:	10.1038/s41597-020-00699-5
Abstrakt:	Simultaneous [18 F]-fluorodeoxyglucose positron emission tomography and functional magnetic resonance imaging (FDG-PET/fMRI) provides the capability to image two sources of energetic dynamics in the brain - cerebral glucose uptake and the cerebrovascular haemodynamic response. Resting-state fMRI connectivity has been enormously useful for characterising interactions between distributed brain regions in humans. Metabolic connectivity has recently emerged as a complementary measure to investigate brain network dynamics. Functional PET (fPET) is a new approach for measuring FDG uptake with high temporal resolution and has recently shown promise for assessing the dynamics of neural metabolism. Simultaneous fMRI/fPET is a relatively new hybrid imaging modality, with only a few biomedical imaging research facilities able to acquire FDG PET and BOLD fMRI data simultaneously. We present data for n = 27 healthy young adults (18-20 yrs) who underwent a 95-min simultaneous fMRI/fPET scan while resting with their eyes open. This dataset provides significant re-use value to understand the neural dynamics of glucose metabolism and the haemodynamic response, the synchrony, and interaction between these measures, and the development of new single- and multi-modality image preparation and analysis procedures.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu