| Autor: |
Gowen BH; Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA., Reyes MV; Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA., Joseph LC; Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA., Morrow JP; Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. |
| Abstrakt: |
Cardiac arrhythmias are responsible for many cardiovascular disease-related deaths worldwide. While arrhythmia pathogenesis is complex, there is increasing evidence for metabolic causes. Obesity, diabetes, and chronically consuming high-fat foods significantly increase the likelihood of developing arrhythmias. Although these correlations are well established, mechanistic explanations connecting a high-fat diet (HFD) to arrhythmogenesis are incomplete, although oxidative stress appears to be critical. This review investigates the metabolic changes that occur in obesity and after HFD. Potential therapies to prevent or treat arrhythmias are discussed, including antioxidants. |
