Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features.

Autor: Grenier K; Department of Pathology, McGill University Health Center, 1001 Decarie Blvd, Montreal, Québec, Canada H4A 3J1., Altinel G; Department of Pathology, McGill University Health Center, 1001 Decarie Blvd, Montreal, Québec, Canada H4A 3J1., Dastani Z; Département de Pathologie, Centre Hospitalier de Lanaudière, 1000 Boulevard Sainte-Anne, Saint-Charles-Borromée, Québec, Canada J6E 6J2., Omeroglu A; Department of Pathology, McGill University Health Center, 1001 Decarie Blvd, Montreal, Québec, Canada H4A 3J1.
Jazyk: angličtina
Zdroj: Case reports in pathology [Case Rep Pathol] 2020 Oct 07; Vol. 2020, pp. 8879035. Date of Electronic Publication: 2020 Oct 07 (Print Publication: 2020).
DOI: 10.1155/2020/8879035
Abstrakt: Epithelial-myoepithelial carcinoma of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. Myoepithelial cells are known to adopt varied morphologies, including spindle, chondroid, clear cell, and rhabdoid morphologies, and can represent a diagnostic challenge when isolated on biopsy. Rhabdomyosarcoma, phyllodes tumor, metaplastic carcinoma, and myoepithelial carcinoma are primary breast tumors that all have been shown to exhibit rhabdoid features, whether representing true differentiation or morphological mimic. We here report an epithelial-myoepithelial carcinoma of the breast with rhabdoid features in a 76-year-old woman. The rhabdoid-appearing myoepithelial cells are negative for myogenin, consistent with a rhabdoid-like morphology rather than a true rhabdoid differentiation, comparably to previously described myoepithelial carcinoma with rhabdoid features. To our knowledge, this is the first reported case of epithelial-myoepithelial carcinoma of the breast with rhabdoid features and thus adds another entity to the differential diagnosis of breast lesions with rhabdoid features.
Competing Interests: There are no conflicts of interests.
(Copyright © 2020 Karl Grenier et al.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje