Chronic resveratrol consumption prevents hypertension development altering electrophysiological currents and Ca 2+ signaling in chromaffin cells from SHR rats.

Autor: Bomfim GHS; Departamento de Farmacología y Terapéutica, Facultad de Medicina, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (ITH/UAM), Madrid, Spain; Department of Molecular Pathobiology, New York University College of Dentistry (NYU), New York, USA. Electronic address: ghs5@nyu.edu., Musial DC; Departamento de Farmacologia, Escola Paulista de Medicina da Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil., Méndez-López I; Departamento de Farmacología y Terapéutica, Facultad de Medicina, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (ITH/UAM), Madrid, Spain., Jurkiewicz A; Departamento de Farmacologia, Escola Paulista de Medicina da Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil., Jurkiewicz NH; Departamento de Farmacologia, Escola Paulista de Medicina da Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil., Padín JF; Departamento de Ciencias Médicas, Facultad de Medicina, Universidad Castilla La Mancha (UCLM), Ciudad Real, Spain., García AG; Departamento de Farmacología y Terapéutica, Facultad de Medicina, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (ITH/UAM), Madrid, Spain; Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Jazyk: angličtina
Zdroj: Cellular signalling [Cell Signal] 2020 Dec; Vol. 76, pp. 109811. Date of Electronic Publication: 2020 Oct 17.
DOI: 10.1016/j.cellsig.2020.109811
Abstrakt: Resveratrol (RESV) is one of the most abundant polyphenol-stilbene compounds found in red wine with well-established cardioprotective and antihypertensive effects. Hyperactivity of the sympathoadrenal axis seems to be one of the major contributing factors in the pathogenesis of human essential hypertension. Alterations in outward voltage-dependent potassium currents (I K ) and inward voltage-dependent sodium (I Na ), calcium (I Ca ) and nicotinic (I ACh ) currents, CCs excitability, Ca 2+ homeostasis, and catecholamine exocytosis were previously related to the hypertensive state. This raised the issue of whether in vivo long-term RESV treatment can directly act as a modulator of Ca 2+ influx or a regulator of ion channel permeability in CCs. We monitored outward and inward currents, and cytosolic Ca 2+ concentrations ([Ca 2+ ] c ) using different pharmacological approaches in CCs from normotensive (WKY) and hypertensive (SHR) animals chronically exposed to trans-RESV (50 mg/L/v.o, 28 days). The long-term RESV treatment prevented the increase of the systolic blood pressure (SBP) in SHR, without reversion of cardiac hypertrophy. We also found an increase of the outward I K , reduction in inward I Na, I Ca , and I ACh , and the mitigation of [Ca 2+ ] c overload in CCs from SHR at the end of RESV treatment. Our data revealed that electrophysiological alterations of the CCs and in its Ca 2+ homeostasis are potential new targets related to the antihypertensive effects of long-term RESV treatment.
(Copyright © 2020. Published by Elsevier Inc.)
Databáze: MEDLINE
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