| Autor: |
Kavanagh SE; Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland., Gilheany DG; Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland. |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2020 Nov 06; Vol. 22 (21), pp. 8198-8203. Date of Electronic Publication: 2020 Oct 19. |
| DOI: |
10.1021/acs.orglett.0c02629 |
| Abstrakt: |
A series of N -substituted cyclohexyldiaminophenolic ligands for the asymmetric Grignard synthesis of tertiary alcohols is reported. The 2,5-dimethylpyrrole-decorated ligand led to improved enantioselectivities and broadened the scope of the methodology. As an exemplar, we report an unprecedented highly selective one-step synthesis of gossonorol in 93% ee , also constituting the shortest formal syntheses of natural products boivinianin B and yingzhaosu C. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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